[关键词]
[摘要]
目的 研究富马酸卢帕他定片联合依巴斯汀片治疗慢性荨麻疹的临床疗效。方法 选取2018年12月-2019年12月在辽宁省健康产业集团抚矿总医院治疗的70例慢性荨麻疹患者为研究对象,所有患者随机分为对照组和治疗组,每组各35例。对照组患者口服依巴斯汀片,1片/次,1次/d。治疗组在对照组基础上口服富马酸卢帕他定片,1片/次,1次/d,两组患者持续治疗4周。观察两组患者治疗后临床疗效,比较两组症状积分、皮肤病生活质量指数(DLQI)评分、外周血免疫球蛋白E(IgE)和补体C3、C4水平、血清炎性因子水平。结果 治疗后,治疗组总有效率为94.29%,显著高于对照组的80.00%(P<0.05)。治疗后,两组患者瘙痒、风团直径、风团数目积分和DLQI评分显著降低(P<0.05);并且治疗组降低较多(P<0.05)。治疗后,两组患者外周血IgE水平显著降低,外周血补体C3、C4水平均明显升高(P<0.05),且治疗组免疫功能指标水平改善较多(P<0.05)。治疗后,两组血清白细胞介素(IL)-2、白细胞介素(IL)-12和IFN-γ水平显著升高(P<0.05);并且治疗组血清炎性因子水平升高较多(P<0.05)。结论 富马酸卢帕他定片联合依巴斯汀片治疗慢性荨麻疹具有较好的治疗效果,能改善患者临床症状,提高患者免疫功能,降低血清炎性因子水平,值得在临床上推广应用。
[Key word]
[Abstract]
Objective To study the efficacy of Rupatadine Fumarate Tablets combined with Ebastine Tablets in treatment of chronic urticaria. Methods Patients (70 cases) with chronic urticaria in Fukuang General Hospital of Liaoning Health Industry Group from December 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Ebastine Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Rupatadine Fumarate Tablets on the basis of the control group, 1 tablet/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom score, DLQI score, IgE, C3, C4, and inflammatory factor in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.29%, which was significantly higher than 80.00% of the control group (P<0.05). After treatment, the scores of pruritus, diameter and number and the DLQI score in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IgE in peripheral blood of the two groups were significantly decreased, but the levels of complement C3 and C4 in peripheral blood of the two groups were significantly increased (P<0.05). And the levels of immune function in the treatment group were improved more than that in the control group (P<0.05). After treatment, the serum levels of IL-2, IL-12, and IFN-γ in the two groups were significantly increased (P<0.05). And the serum levels of inflammatory factors in the treatment group were higher than those in the control group (P<0.05). Conclusion Rupatadine combined with Ebastine Tablets has clinical curative effect in treatment of chronic urticaria, can improve the clinical symptoms and the immune function, and reduce the serum level of inflammatory factors, which is worthy of clinical application.
[中图分类号]
R977
[基金项目]
辽宁省自然科学基金资助项目(20180550670)