帕金森病是常见的神经系统变性疾病，药物治疗仍是目前临床上控制和缓解其症状的主要方法。多巴胺受体激动剂作为治疗帕金森病的新型手段，不仅能在早期改善患者临床症状，而且在晚期显著延缓和减轻运动并发症，因此受到药物研发人员越来越多的关注。持续、稳定的多巴胺受体刺激是控制帕金森病的有效手段，基于此理论，多巴胺受体激动剂缓释制剂发展迅速，主要对其缓释剂型及研究进展进行综述。

Parkinson’s disease is a common neurodegenerative disease. At present, drug therapy is still the main method to control and relieve its symptoms in clinic. As a new treatment for Parkinson’s disease, dopamine receptor agonists can not only improve the clinical symptoms of patients in the early stage, but also significantly delay and attenuates motor complications in advanced stage of Parkinson’s disease, which has attracted more and more attention of drug researchers. Continuous dopamine-receptor stimulation is an effective therapy to control Parkinson’s disease. Based on this theory, the sustained-release systems of dopamine receptor agonist have developed rapidly. The research progress on dopamine receptor agonists sustained-release preparation is reviewed in this paper.

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