[关键词]
[摘要]
目的 分析舒肝宁注射液致过敏反应的病例及相关文献,为临床医护人员使用舒肝宁注射液提供对策建议。方法 检索中文科技期刊全文数据库(维普)、中国学术期刊(网络版)、万方数字化期刊全文库和大医医学搜索数据库以及NGC、NICE、Cochrane、Pubmed,对2000—2019年因舒肝宁注射液致过敏反应的文献报道和重庆市涪陵中心医院1例舒肝宁注射液致过敏性休克病例进行分析。结果 舒肝宁注射液过敏反应病例中男性多于女性,年龄主要集中于≥61岁。有3例过敏史患者和3例哮喘史患者。10 min内发生的不良反应有9例,构成比为40.9%。20 mL用药剂量的构成比最大,为54.5%;溶媒主要为5%葡萄糖注射液和10%葡萄糖注射液。有1例联合配伍使用。过敏反应累及的器官/系统主要包括皮肤、循环系统、呼吸系统等,具体临床表现主要为皮疹、瘙痒和心率异常等。结论 临床应高度重视舒肝宁注射液致过敏反应的风险,熟悉舒肝宁注射液致过敏反应的特征和影响因素,用药前详细询问哮喘史,开始输入的30 min严密巡视,用药中加强观察,避免发生严重后果。
[Key word]
[Abstract]
Objective To analyze the cases and related articles of allergic reaction induced by Shuganning Injection, and to provide suggestions for clinical medical staff to use Shuganning Injection. Methods Literatures about allergic reaction induced by Shuganning Injection were collected from Chinese Science and Technology Journal Full-text Database (VIP), Chinese Academic Journal (online), Wangfang Database, University Medical Search Database, NGC, NICE, Cochrane, and Pubmed from 2000 to 2019, and the case of Fuling Center Hospital of Chongqing City were analyzed statistically. Results Male were more than female in the cases of allergic reaction induced by Shuganning Injection, and they were above 61 years old. There were 3 cases of patients with history of allergy and 3 cases of patients with history of asthma. There were 9 cases of allergy within 10 min, accounting for 40.9%. Most dose of medication was 20 mL, accounting for 54.5%. The solvent were 5% Glucose Injection and 10% Glucose Injection. There was only one cases of use in combination. The organ/system involved by allergic reaction mainly consisted of the skin, circulatory system, and the respiratory system, and the specific clinical manifestations were mainly rash, pruritus, and abnormalities in heart rate. Conclusion In clinical practice, the risk of allergy caused by Shuganing Injection should be attached great importance to, and the characteristics and influencing factors of allergic reactions should be known well with. Before medication, the history of asthma should be inquired about, and tight patrol should be carried in the first 30 minutes, and observation should be strengthened during medication, in order to avoiding serious consequences.
[中图分类号]
R976
[基金项目]
重庆市技术创新与应用发展专项(cstc2019jscx-msxmX0082)