目的 研究灯台叶颗粒联合孟鲁司特钠片治疗小儿迁延性肺炎的临床疗效。方法 选取2018年10月—2019年10月在河南省儿童医院治疗的120例迁延性肺炎患儿，将所有患儿随机分为对照组和治疗组，每组各60例。对照组患儿口服孟鲁司特钠片，5 mg/次，1次/d。治疗组在对照组治疗的基础上口服灯台叶颗粒，10 g/次，3次/d。两组患儿持续治疗10 d。观察两组的临床疗效，比较两组的复发情况、临床症状好转时间、肺功能指标、血清炎性指标。结果 治疗后，治疗组总有效率（96.67%）显著高于对照组（83.33%）（P<0.05），治疗组复发率（1.67%）显著低于对照组（13.33%）（P<0.05）。治疗后，治疗组患儿退热时间、止咳时间、肺部湿啰音消失时间明显短于对照组（P<0.05）。治疗后，两组患儿一秒用力呼气量（FEV1）、用力肺活量（FVC）、FEV1/FVC显著升高（P<0.05），且治疗组肺功能指标升高较多（P<0.05）。治疗后，两组患儿血清C-反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）水平显著降低（P<0.05）；并且治疗组血清炎性指标水平降低较多（P<0.05）。结论 灯台叶颗粒联合孟鲁司特钠片治疗小儿迁延性肺炎具有较好的临床疗效，能够改善患儿肺功能，降低血清炎症指标水平，值得在临床上推广应用。

Objective To study the curative effect of Dengtaiye Granules combined with Montelukast Sodium Tablets in treatment of children’s persistent pneumonia. Methods Children (120 cases) with persistent pneumonia in Henan Children’s Hospital from October 2018 to October 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Children in the control group were po administered with Montelukast Sodium Tablets, 5 mg/time, once daily. Children in the treatment group were po administered with Dengtaiye Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and recurrence rates, clinical symptom relief times, pulmonary function indexes, serum levels of inflammatory indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group (96.67%) was significantly higher than that of the control group (83.33%) (P<0.05), and the recurrence rate of the treatment group (1.67%) was significantly lower than that of the control group (13.33%) (P<0.05). After treatment, the antipyretic time, antitussive time, and disappearance time of lung wet rales in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, FEV1, FVC, and FEV1/FVC in two groups were significantly increased (P<0.05), and the pulmonary function indexes in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the serum levels of CRP, TNF-α, and IL-6 in the two groups were significantly decreased (P<0.05). After treatment, the serum levels of inflammatory indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Dengtaiye Granules combined with Montelukast Sodium Tablets has clinical curative effect in treatment of children’s persistent pneumonia, can improve the lung function of children and reduce the serum level of inflammation indexes, which is worthy of clinical application.

R974