目的 研究齿痛消炎灵颗粒联合盐酸米诺环素软膏治疗急性智齿冠周炎的临床疗效。方法 选取2016年8月—2019年8月在漯河医学高等专科学校第二附属医院治疗的80例急性智齿冠周炎患者，所有患者随机分为对照组和治疗组，每组各40例。对照组患者口腔清洗后将盐酸米诺环素软膏注满患部牙周袋内，1次/周；治疗组在对照组基础上口服齿痛消炎灵颗粒，1袋/次，3次/d。两组患者持续治疗4周。观察两组的临床疗效，比较两组患者的视觉模拟评分法（VAS）评分、牙龈指数（GI）、临床症状缓解时间、龈沟液因子白细胞介素-1（IL-1）、肿瘤坏死因子-α（TNF-α）和前列腺素E₂（PGE₂）水平。结果 治疗后，对照组和治疗组的总有效率分别为77.50%、92.50%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者VAS评分和GI均显著降低（P<0.05）；且治疗组VAS评分和GI降低较多（P<0.05）。治疗后，治疗组牙齿肿痛、张口受限、全身症状消失时间明显短于对照组（P<0.05）。治疗后，两组患者IL-1、TNF-α和PGE₂水平显著降低（P<0.05）；并且治疗组龈沟液因子水平降低较多（P<0.05）。结论 齿痛消炎灵颗粒联合盐酸米诺环素软膏治疗急性智齿冠周炎具有较好的治疗效果，可缓解临床症状，减少疼痛，降低龈沟液因子水平，值得在临床上推广应用。

Objective To study the effect of Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment in treatment of acute pericoronitis of wisdom teeth. Methods Patients (80 cases) with acute pericoronitis of wisdom teeth in the Second Affiliated Hospital of Luohe Medical College from August 2016 to August 2019 were randomly divided into control and treatment groups, and each group had 40 cases. After oral cleaning, the periodontal bags of patients in the control group were filled with Minocycline Hydrochloride Ointment, once weekly. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and VAS score, GI, clinical symptom remission time, levels of IL-1, TNF-α, and PGE2 in gingival crevicular fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.50% and 92.50%, respectively (P<0.05). After treatment, the VAS score and GI in the two groups were significantly decreased (P<0.05), and the VAS score and GI in the treatment group were significantly lower than those in the control group (P<0.05).After treatment, the disappearance time of swelling and pain, mouth opening limitation and systemic symptoms in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of IL-1, TNF-α, and PGE₂ in the two groups were significantly decreased (P<0.05), and the gingival crevicular fluid factors in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment has clinical curative effect in treatment of acute pericoronitis of wisdom teeth, can alleviate clinical symptoms, reduce pain, and reduce the factor level of gingival crevicular fluid, which is worthy of clinical application.

R988.2