目的 探讨癫痫宁片联合丙戊酸钠片治疗颅脑外伤术后癫痫的临床疗效。方法 选择2017年1月—2018年12月平煤神马医疗集团总医院收治的115例颅脑外伤所致癫痫患者作为研究对象，随机将所有患者分为对照组（57例）和治疗组（58例）。对照组患者口服丙戊酸钠片，15 mg/（kg·d），分2～3次口服；治疗组在对照组治疗的基础上口服癫痫宁片，4片/次，3次/d。两组患者连续治疗3个月。比较两组患者的临床疗效，对癫痫发作情况、神经递质、炎性因子、生化指标进行比较分析。结果 治疗后，对照组患者总有效率为77.19%，而治疗组总有效率为89.65%，组间差异有显著性（P<0.05）。治疗后，两组患者癫痫的发作次数、持续时间均持续降低（P<0.05），且治疗组的发作次数、持续时间均明显更低（P<0.05）。治疗后，两组患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C反应蛋白（CRP）水平显著下降（P<0.05），且治疗后治疗组患者的TNF-α、IL-6、CRP水平下降程度更多（P<0.05）。治疗后，治疗组患者一氧化氮（NO）水平、总抗氧化能力（T-AOC）显著升高，丙二醛（MDA）水平明显降低（P<0.05），且治疗后治疗组患者各指标改善程度明显高于对照组（P<0.05）。治疗后，两组患者γ-氨基丁酸（GABA）含量增加，谷氨酸（Glu）、天冬氨酸（Asp）水平明显下降（P<0.05），而治疗后治疗组患者神经递质含量改善程度明显更高（P<0.05）。结论 癫痫宁片联合丙戊酸钠片治疗颅脑外伤术后癫痫具有较好的临床疗效，可显著降低患者的发作频率和发作时间，提高机体的抗炎抗氧化能力，值得临床推广。

Objective To investigate the clinical study of Dianxianning Tablets combined with Sodium Valproate Tablets in treatment of epilepsy after craniocerebral trauma. Methods Patients (115 cases) with epilepsy after craniocerebral trauma in Pingmei Shenma Medical Group General Hospital from January 2017 to December 2018 were randomly divided into control group (57 cases) and treatment group (58 cases). Patients in the control group were po administered with Sodium Valproate Tablets, 15 mg/(kg·d), took orally in 2 — 3 times. Patients in the treatment group were po administered with Dianxianning Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and epileptic seizure, inflammatory factors, biochemical indicators, and neurotransmitter content in two groups were compared. Results After treatment, the total effective rate of the control group was 77.19%, while the total effective rate of the treatment group was 89.65%, and the difference between the groups was significant (P<0.05). After treatment, the frequency and duration of epilepsy in the two groups were significantly decreased (P<0.05), and the frequency and duration of epilepsy in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, and CRP in two groups were significantly decreased (P<0.05). And the levels of TNF-α, IL-6, and CRP in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, NO and T-AOC in two groups were significantly increased, but the levels of MDA in two groups were significantly decreased (P<0.05). And the inflammatory factors in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the GABA in two groups were significantly increased, but Glu and Asp in two groups were significantly decreased (P<0.05). And the biochemical indicators in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Dianxianning Tablets combined with Sodium Valproate Tablets has clinical curative effect in treatment of epilepsy after craniocerebral trauma, can significantly reduce the frequency and time of seizures, improve the body’s anti-inflammatory and anti-oxidation ability, which is worthy of clinical promotion.

R971