目的 观察六经头痛片联合盐酸氟桂利嗪治疗偏头痛的临床效果。方法 选择2017年1月—2018年11月郑州煤炭工业（集团）有限责任公司米村煤矿职工医院收治的偏头痛患者123例，随机分为对照组（62例）和治疗组（61例）。对照组患者睡前口服盐酸氟桂利嗪胶囊，2粒/次，1次/d。治疗组在对照组用药基础上口服六经头痛片，3片/次，3次/d。两组患者连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者同型半胱氨酸（Hcy）、降钙素基因相关肽（CGRP）、5-羟色胺（5-HT）水平，大脑后动脉（PCA）、大脑前动脉（ACA）和大脑中动脉（MCA）血流速度，以及视觉模拟评分法（VAS）评分和头痛发作频率。结果 治疗后，对照组和治疗组临床有效率分别为77.42%和93.44%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Hcy和CGRP水平显著降低（P<0.05），而5-HT水平显著升高（P<0.05）；且治疗组患者Hcy、CGRP和5-HT水平改善效果明显优于对照组（P<0.05）。治疗后，两组患者PCA、ACA和MCA血流速度水平，以及VAS评分和头痛发作频率均明显降低（P<0.05），且治疗组患者明显比对照组低（P<0.05）。结论 六经头痛片联合盐酸氟桂利嗪治疗偏头痛可降低患者疼痛次数，降低脑血流速度，安全可靠，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Liujing Toutong Tablets combined with flunarizine in treatment of migraine. Methods Patients (123 cases) with migraine in Micun Coal Mine Staff Hospital of Zhengzhou coal industry (Group) Co., Ltd from January 2017 to November 2018 were randomly divided into control (62 cases) and treatment (61 cases) groups. Patients in the control group were po administered with Flunarizine Hydrochloride Capsules before bed, 2 grains/time, once daily. Patients in the treatment group were po administered with Liujing Toutong Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the level of Hcy, CGRP and 5-HT, blood flow velocity of PCA, ACA and MCA, VAS and frequency of headache attack in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 77.42% and 93.44% respectively, and there were differences between two groups (P<0.05). After treatment, the Hcy and CGRP level in two groups was significantly decreased (P<0.05), but the 5-HT level was significantly increased (P<0.05), and the level of Hcy, CGRP and 5-HT in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the blood flow velocity of PCA, ACA and MCA, VAS and frequency of headache attack in two groups were significantly decreased (P<0.05), and these indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Liujing Toutong Tablets combined with flunarizine in treatment of migraine can reduce the frequency of pain and attacks, reduce cerebral blood flow velocity, which is safe and reliable, and has a certain clinical application value.

R971