目的 探讨银杏酮酯片联合丁苯酞软胶囊治疗血管性轻度认知功能障碍的临床疗效。方法 选取2018年3月—2019年11月在天津市中医药研究院附属医院就诊的102例血管性轻度认知功能障碍患者作为本研究对象，按照随机数字表法将全部患者分为对照组和治疗组，每组各51例。对照组口服丁苯酞软胶囊，0.2 g/次，3次/d。治疗组在对照组基础上口服银杏酮酯片，0.15 g/次，3次/d。两组患者连续治疗12周。观察两组的临床疗效，比较两组的治疗前后生活质量情况、血清炎症因子、血清神经功能指标水平。结果 治疗后，治疗组患者的总有效率（94.12%）比对照组高（80.39%）（P<0.05）。治疗后，两组的白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、同型半胱氨酸（Hcy）水平明显降低（P<0.05）；治疗后治疗组的IL-6、TNF-α、Hcy水平比对照组低（P<0.05）。治疗后，两组的脑髓鞘碱性蛋白（MBP）、中枢神经特异蛋白（S100β）、神经元特异性烯醇化酶（NSE）水平明显降低（P<0.05）；治疗后治疗组的MBP、S100β、NSE水平低于对照组（P<0.05）。治疗后，两组的简易精神状态量表（MMSE）评分、日常生活能力量表（ADL）评分明显升高（P<0.05）；治疗后治疗组的MMSE评分、ADL评分高于对照组（P<0.05）。结论 银杏酮酯片联合丁苯酞软胶囊治疗血管性轻度认知功能障碍的临床疗效较好，可改善认知功能和生活质量，减轻炎症反应和降低神经功能的损伤，具有良好的临床研究价值。

Objective To investigate the clinical effect of Yinxing Tongzhi Tablets combined with Butylphthalide Soft Capsules in treatment of vascular mild cognitive impairment. Methods Patients (102 cases) with vascular mild cognitive impairment in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from March 2018 to November 2019 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were po administered with Butylphthalide Soft Capsules, 0.2 g/time, three times daily. Patients in the treatment group were po administered with Yinxing Tongzhi Tablets on the basis of the control group, 0.15 g/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and quality of life, inflammatory factor, and serum neurological indexes were compared. Results After treatment, the total effective rate of the treatment group (94.12%) was higher than that of the control group (80.39%) (P<0.05). After treatment, the levels of IL-6, TNF-α, and Hcy in the two groups were significantly decreased (P<0.05). After treatment, the levels of IL-6, TNF-α, and Hcy in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of MBP, S100β, and NSE in the two groups were significantly decreased (P<0.05). After treatment, the levels of MBP, S100β and NSE in the treatment group were lower than those in the control group (P<0.05). After treatment, the MMSE scores and ADL scores of the two groups were significantly increased (P<0.05). After treatment, the MMSE score and ADL score of the treatment group were higher than those of the control group (P<0.05).Conclusion Yinxing Tongzhi Tablets combined with Butylphthalide Soft Capsules has clinical curative effect in treatment of vascular mild cognitive impairment, can improve the cognitive function and quality of life, reduce the inflammatory response and reduce the damage of nerve function, which has good clinical research value.

R971

天津市科技计划项目（18 ZXDBSY00080）