目的 研究安神胶囊联合富马酸喹硫平片治疗精神分裂症的临床疗效。方法 选取2016年9月—2019年9月在天津市安定医院治疗的100例精神分裂症患者为研究对象，将患者随机分为对照组和治疗组，每组各50例。对照组患者口服富马酸喹硫平片，第1、2、3、4天分别给予50、100、200、300 mg，之后剂量逐渐增加到有效剂量范围300～450 mg/d，2次/d；治疗组患者在对照组基础上口服安神胶囊，4粒/次，3次/d。两组患者持续治疗2个月。观察两组患者临床疗效，比较两组的阳性和阴性症状量表（PANSS）评分、生活质量综合评定问卷（GQOLI-74）评分和简明精神病量表（BPRS）评分以及血清学指标。结果 治疗后，治疗组总有效率显著高于对照组（P<0.05）。治疗后，两组患者PANSS评分和BPRS评分明显降低，GQOLI-74评分明显升高（P<0.05），且治疗组改善较多（P<0.05）。治疗后，两组患者神经元特异性烯醇化酶（NSE）、碱性髓鞘蛋白（MBP）水平均明显降低，脑源性神经营养因子（BDNF）、胶质细胞系来源神经营养因子（GDNF）水平均明显升高（P<0.05）；且治疗组改善较多（P<0.05）。结论 安神胶囊联合富马酸喹硫平片治疗精神分裂症具有较好的治疗效果，能够改善患者临床症状，降低血清炎性因子水平，安全性较高，值得在临床上推广应用。

Objective To study the clinical efficacy of Anshen Capsules combined with Quetiapine Fumarate Tablets in treatment of schizophrenia. Methods Patients (100 case) with schizophrenia in Tianjin Anding Hospital from September 2016 to September 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Quetiapine Fumarate Tablets, 50 mg on the first day, then 100, 200, and 300 mg on the other day, after that, the dose gradually increased to the effective dose range 300 — 450 mg/d in general, twice daily. Patients in the treatment group were po administered with Anshen Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and PANSS scores, GQOLI-74 scores, BPRS scores, and serological indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). After treatment, PANSS score and BPRS score of two groups were significantly decreased, but GQOLI-74 score of two groups were significantly increased (P<0.05), and the observational scores of the treatment group were more significantly improved (P<0.05). After treatment, the serum levels of NSE and MBP in two groups were significantly decreased, but the levels of BDNF and GDNF in two groups were significantly increased (P<0.05). And the inflammatory factor levels of the treatment group were more significantly improved (P<0.05). Conclusion Anshen Capsules combined with Quetiapine Fumarate Tablets has clinical curative effect in treatment of schizophrenia, can improve the clinical symptoms of patients, reduce the serum level of inflammatory factors, with high safety, which is worthy of clinical application.

R971

国家重点研发计划课题（2018YFC1314304）