[关键词]
[摘要]
目的 探讨丹参川芎嗪注射液联合羟苯磺酸钙分散片治疗糖尿病视网膜病变的临床疗效。方法 选取2018年8月—2019年12月收治的92例糖尿病视网膜病变患者作为研究对象,所有患者按照随机数字表法分为对照组和治疗组,每组各46例。对照组口服羟苯磺酸钙分散片,0.5 g/次,3次/d。治疗组患者在对照组基础上静脉滴注丹参川芎嗪注射液,5 mL/次,1次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组的视力指标和视网膜血流动力学指标。结果 治疗后,治疗组患者的总有效率(93.48%)比对照组(78.26%)高,差异有统计学意义(P<0.05)。治疗后,两组的视力值明显升高,视野平均缺损指数、视野灰度值明显降低(P<0.05);治疗后治疗组的视力值比对照组高,视野平均缺损指数、视野灰度值比对照组低(P<0.05)。治疗后,两组眼动脉、视网膜中央动脉的峰值血流速度(PSV)明显升高,阻力指数(RI)明显降低(P<0.05);治疗后治疗组的眼动脉、视网膜中央动脉的PSV比对照组高,RI比对照组低(P<0.05)。结论 丹参川芎嗪注射液联合羟苯磺酸钙分散片治疗糖尿病视网膜病变具有较好的临床疗效,能改善视力状况和眼部血流动力学水平,具有良好的临床研究价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Calcium Dobesilate Dispersible Tablets in treatment of diabetic retinopathy. Methods Patients (92 cases) with diabetic retinopathy in the Fifth Affiliated Hospital of Zhengzhou University from August 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Calcium Dobesilate Dispersible Tablets, 0.5 g/time, three times daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 5 mL/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and visual acuity and retinal hemodynamic parameters in two groups were compared. Results After treatment, the total effective rate of the treatment group (93.48%) was higher than that of the control group (78.26%), and the difference was statistically significant (P<0.05). After treatment, the visual acuity values of two groups were significantly increased, but visual field average defect index and visual field gray value were significantly decreased (P<0.05). After treatment, the visual acuity value of the treatment group was higher than that of the control group, but visual field average defect index and visual field gray value were lower than those in the control group (P<0.05). After treatment, the PSV of ophthalmic artery and central retinal artery in the two groups were significantly increased, but the RI of ophthalmic artery and central retinal artery in the two groups were significantly decreased (P<0.05). After treatment, the PSV of ophthalmic artery and central retinal artery in the treatment group was higher than that in the control group, and RI of ophthalmic artery and central retinal artery in the treatment group was lower than that in the control group (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Calcium Dobesilate Dispersible Tablets has clinical curative effect in treatment of diabetic retinopathy, can improve visual acuity and ocular hemodynamics, which has good clinical research value.
[中图分类号]
R977
[基金项目]
河南省医学科技攻关计划省部共建项目(sb201903012)