目的 探讨金蝉止痒胶囊联合富马酸卢帕他定片治疗慢性荨麻疹的临床疗效。方法 选取2019年2月-2019年6月在长沙市中医医院诊治的86例慢性荨麻疹患者，根据用药的差别分为对照组（43例）和治疗组（43例）。对照组口服富马酸卢帕他定片，10 mg/次，1次/d；治疗组在对照组基础上口服金蝉止痒胶囊，3 g/次，3次/d。两组患者均经4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、UAS和DLQI评分及血清白细胞介素-4（IL-4）、白细胞介素-17（IL-17）、白三烯（LT）、可溶性血管细胞黏附分子（sVCAM-1）和干扰素-γ（IFN-γ）水平。结果 治疗后，对照组和治疗组临床有效率分别为81.40%和97.67%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者症状积分、UAS评分、DLQI评分均明显下降（P<0.05），且治疗组比对照组下降更明显（P<0.05）。经治疗，两组患者血清IL-4、IL-17、LT、sVCAM-1水平均显著降低（P<0.05），而IFN-γ水平明显升高（P<0.05），且治疗组患者这些血清学指标水平明显好于对照组（P<0.05）。结论 金蝉止痒胶囊联合富马酸卢帕他定片治疗慢性荨麻疹可有效改善患儿临床症状，降低机体炎症因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jinchan Zhiyang Capsules combined with Rupatadine Fumarate Tablets in treatment of chronic urticaria. Methods Patients (86 cases) with chronic urticaria in Changsha Hospital of Traditional Chinese Medicine from February 2019 to June 2019 were divided into control (43 cases) and treatment (43 cases) groups based on different treatments. Patients in the control group were po administered with Peramivir and Sodium Chloride Injection, 10 mg/time, once daily. Patients in the treatment group were po administered with Jinchan Zhiyang Capsules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, UAS and DLQI score, the serum level of IL-4, IL-17, LT, IFN-γ and sVCAM-1 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67%, respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores, UAS and DLQI score in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the serum level of IL-4, IL-17, LT and sVCAM-1 in two groups was significantly decreased (P<0.05), but the level of IFN-γ level was significantly increased (P<0.05), and the serological indexes level in the treatment group was significantly better than that in the control group (P<0.05). Conclusion Jinchan Zhiyang Capsules combined with Rupatadine Fumarate Tablets in treatment of chronic urticaria can effectively improve the clinical symptoms, reduce the level of inflammatory factors, which has a certain clinical application value.

R986