目的 研究茵栀黄口服液联合注射用还原型谷胱甘肽治疗新生儿黄疸的临床疗效。方法 选取2016年12月-2017年12月在青海省妇女儿童医院进行治疗的100例新生儿黄疸患儿作为研究对象，采用随机数字表法将所有患儿分为对照组和治疗组，每组各50例。对照组患儿静脉滴注注射用谷胱甘肽，0.6 g加入到5%葡萄糖注射液100 mL中，1次/d；治疗组在对照组治疗的基础上口服茵栀黄口服液，2.5 mL/次，3次/d。两组患儿持续治疗2周。观察两组的临床疗效，比较两组的临床症状缓解时间、生化指标水平、血清炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为80.00%、94.00%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患儿退黄时间、胎便排空时间显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿血清总胆红素（TBIL）、结合胆红素（DBIL）、丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转氨酶（AST）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患儿血清TBIL、DBIL、ALT、AST水平均明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患儿IL-1、IL-6、TNF-α水平均明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 茵栀黄口服液联合注射用还原型谷胱甘肽治疗新生儿黄疸具有较好的临床疗效，能改善患儿临床症状和肝功能，调节血清炎性因子水平，具有一定的临床推广应用价值。

Objective To study the effect of Yinzhihuang Oral Liquid combined with Reduced Glutathione for injection in treatment of neonatal jaundice. Methods Children (100 cases) with neonatal jaundice in Qinghai Women's and Children's Hospital from December 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Children in the control group were iv administered with Reduced Glutathione for injection, 0.6 g added into 5% glucose solution 100 mL, once daily. Children in the treatment group were po administered with Yinzhihuang Oral Liquid on the basis of the control group, 2.5 mL/time, three times daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom remission time, biochemical index levels, and serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 94.00%, respectively, and there was difference between two groups (P<0.05). After treatment, removing jaundice time and the evacuation time of meconium in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of TBIL, DBIL, ALT and AST in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the biochemical index levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-1, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yinzhihuang Oral Liquid combined with Reduced Glutathione for injection has clinical curative effect in treatment of neonatal jaundice, can improve the clinical symptoms and liver function, and regulate the serum level of inflammatory factors, which has a certain clinical application value.

R985