益生菌是一类活的非致病性微生物，大量摄入能够使人体肠道菌群正常化，并对健康有潜在益处。自身免疫病是一类由于自身免疫耐受被打破而导致器官组织损害的慢性炎症性疾病，包括常见的类风湿性关节炎、系统性红斑狼疮、多发性硬化等，其发病率呈逐年上升趋势，已有研究证实其发生与菌群失调有关，传统的自身免疫病治疗药物常引发较严重的不良反应，使得疗效受限。益生菌已被证实对多种疾病的治疗具有潜在益处，且具有菌株特异性，探究益生菌用于治疗自身免疫病是目前一大焦点，对此方面的研究进展进行综述，旨在为临床选择治疗方案提供理论支持。

Probiotics are live microorganisms that can normalize gut microbiota and confer a potential beneficial effect on the health when administered in adequate amounts. Autoimmune diseases are chronic inflammatory diseases with organ and tissue damage caused by the breaking of autoimmune tolerance, common examples of autoimmune diseases including reumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, etc. The incidence rate showed an upward trend. It has been confirmed that the occurrence of autoimmune diseases is related to the imbalance of intestinal flora, and traditional therapeutic drugs for autoimmune diseases often bring about serious adverse reactions, which limit the efficacy. Since probiotics have been proved to have strain specific-potential benefits in the treatment of a variety of diseases, their application in autoimmune diseases has increasingly become a research hotspot, and the research progress on this are reviewed in this paper, aiming to provide theoretical support for clinical treatment selection.

福建省大学生创新创业训练计划项目（201912631011）