目的 了解芜湖市第二人民医院静脉药物配置中心抗肿瘤药物的不合理医嘱情况，促进临床合理用药。方法 提取芜湖市第二人民医院2016年1月-2018年12月静脉药物配置中心抗肿瘤药物的不合理医嘱，分析不合理用药原因并进行归类汇总和分析。结果 临床科室存在抗肿瘤药物不合理使用现象，肿瘤介入科的构成比（51.58%）最高，其次为血液科（15.44%）。在审核的33 261份抗肿瘤药物医嘱中，不合理用药285份，构成比为0.86%；不合理用药主要表现在浓度与溶媒量不适宜（54.74%）、给药顺序不适宜（18.24%）、溶媒选择不适宜（17.89%）、给药剂量不适宜（6.32%）、给药途径不适宜（2.81%）。结论 药师应对抗肿瘤药物不合理医嘱进行及时干预，提高临床合理用药水平，减少不良事件的发生。

Objective To analyze the irrational medical orders of antineoplastic drugs in in pharmacy intravenous admixture services in Second People's Hospital of Wuhu, and to promote rational drug use. Methods The irrational medical orders of antineoplastic drugs were collected in pharmacy intravenous admixture services in Second People's Hospital of Wuhu from January 2016 to December 2018, and the reasons of irrational drug use were analyzed and classified. Results The irrational use of antineoplastic drugs were observed in the clinical departments. Department of Oncology had the highest proportion (51.58%), followed by Department of Hematology (15.44%). Among the 33 261 examined antineoplastic drug orders, 285 pieces (0.86%) was unreasonable. The irrational drug use mainly included improper concentration and solvent volume (54.74%), improper sequence of administration (18.24%), improper solvent selection (17.89%), improper dosage (6.32%), and improper route of administration (2.81%). Conclusion Pharmacists should intervene timely the irrational medical orders of antineoplastic drugs to improve the level of rational use, and reduce the occurrence of adverse events.