目的 研究渴络欣胶囊联合复方α-酮酸片治疗糖尿病肾病的临床疗效。方法 选取2017年2月-2019年2月秦皇岛市海港医院收治的60例糖尿病肾病患者为研究对象，所有患者随机分为对照组和治疗组，每组各30例。对照组口服复方α-酮酸片，4片/次，3次/d；治疗组在对照组基础上口服渴络欣胶囊，4粒/次，3次/d。两组患者接受治疗3个月。观察两组的临床疗效，比较两组的肾功能指标、血清炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、93.33%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血肌酐（Scr）、血尿素氮（BUN）和24 h尿蛋白定量水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组肾功能指标水平明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者C反应蛋白（CRP）和白细胞介素-6（IL-6）水平显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患者血清炎性因子水平明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 渴络欣胶囊联合复方α-酮酸片治疗糖尿病肾病具有较好的临床疗效，可改善肾功能，调节血清炎性因子水平，具有一定的临床推广应用价值。

Objective To study the efficacy of Keluoxin Capsules combined with Compound α-Ketoacid Tablets in treatment of diabetic nephropathy. Methods Patients (60 cases) with diabetic nephropathy in Qinhuangdao Harbor Hospital from February 2017 to February 2019 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were po administered with Compound α-Ketoacid Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Keluoxin Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and renal function indexes, and serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 93.33%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of Scr, BUN, and 24 h urine protein quantification in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the renal function indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CRP and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Keluoxin Capsules combined with Compound α-Ketoacid Tablets has clinical curative effect in treatment of diabetic nephropathy, can improve renal function, and regulate the serum levels of inflammatory factors, which has a certain clinical application value.

秦皇岛市科学技术研究与发展计划项目（201602 A175）