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[摘要]
目的 探讨金鸡片联合左氧氟沙星片治疗慢性盆腔炎的临床疗效。方法 选取2017年12月-2018年12月天津市宝坻区人民医院收治100例慢性盆腔炎患者为研究对象,随机分为对照组(48例)和治疗组(52例)。对照组患者口服左氧氟沙星片,100 mg/次,2次/d。治疗组患者在对照组治疗的基础上口服金鸡片,4片/次,3次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组的临床症状消失时间、炎性因子水平、血清因子水平。结果 治疗后,对照组和治疗组的总有效率分别为70.83%、88.46%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患者腰骶胀痛、下腹疼痛、带下异常的消失时间较对照组明显更短,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者C-反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);并且治疗后治疗组患者炎性因子水平均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者前白蛋白水平显著升高,分泌型免疫球蛋白A、内皮素、血栓素水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);并且治疗后治疗组患者血清因子水平均明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 金鸡片联合左氧氟沙星片治疗慢性盆腔炎具有较好的临床疗效,能改善临床症状,降低患者炎性水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the efficiency of Jinji Tablets combined with Levofloxacin Tablets in treatment of chronic pelvic inflammatory disease. Methods Patients (100 cases) with chronic pelvic inflammatory disease in Tianjin Baodi District People's Hospital from December 2017 to December 2018 were randomly divided into the control group (48 cases) and the treatment group (52 cases). Patients in the control group were po administered with Levofloxacin Tablets, 100 mg/time, twice daily. Patients in the treatment group were po administered with Jinji Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms disappeared time, inflammatory factor levels, and serum factor levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.83% and 88.46%, respectively, and there was difference between two groups (P<0.05). After treatment, disappearance time of lumbosacral pain, lower abdominal pain, and subgirdle abnormality in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of CRP, IL-6 and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of prealbumin in two groups were significantly increased, but the levels of secretory immunoglobulin A, endothelin and Thromboxane in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum factor levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jinji Tablets combined with Levofloxacin Tablets has clinical curative effect in treatment of chronic pelvic inflammatory disease, can improve clinical symptoms, and reduce the inflammatory level of patients, which has a certain clinical application value.
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