目的 探讨益妇止血丸联合黄体酮胶囊治疗无排卵型功能失调性子宫出血的临床疗效。方法 选取2017年6月-2018年6月在中国人民武装警察部队河南总队医院治疗的80例无排卵型功能失调性子宫出血患者，根据用药差别分为对照组（40例）和治疗组（40例）。对照组口服黄体酮胶囊，100 mg/次，2次/d；治疗组在对照组基础上口服益妇止血丸，6 g/次，3次/d。两组均以7 d为1个疗程，两组均治疗3个疗程后进行效果比较。观察两组的临床疗效，比较两组治疗前后临床症候积分、相关评分和血清学指标的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是80.0%、97.5%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组阴道流血量评分、失眠多梦评分、腰膝酸软评分、倦怠乏力评分、五心烦热评分均较治疗前显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些临床症状积分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组PBAC评分、SAS评分、SDS评分均较治疗前显著降低，而GQOL-74评分均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组PBAC评分、SAS评分、SDS评分显著低于对照组，而GQOL-74评分低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清血管生成素-2（Ang-2）、雌二醇（E₂）水平均显著降低，而血管内皮生长因子（VEGF）、血红蛋白（HB）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组Ang-2、E₂水平低于对照组，而VEGF、Hb高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 益妇止血丸联合黄体酮胶囊治疗无排卵型功能失调性子宫出血具有较好的临床疗效，可有效改善患者临床症状，改善患者月经状况及焦虑状态，提高患者生活质量，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Yifu Zhixue Pills combined with Progesterone Capsules in treatment of anovulatory dysfunctional uterine bleeding. Methods 80 Patients with anovulatory dysfunctional uterine bleeding in Henan General Hospital of Chinese People's Armed Police Force from June 2017 to June 2018 were divided into control group (40 cases) and treatment group (40 cases) according to the difference of medication. Patients in the control group were po administered with Progesterone Capsules, 100 mg/time, twice daily. Patients in the treatment group were po administered with Yifu Zhixue Pills on the basis of the control group, 6 g/time, three times daily. Both groups were treated with 7 d as one course of treatment, and the effects were compared after 3 courses of treatment in both groups. After treatment, the clinical efficacy was evaluated, and the changes of clinical syndrome scores, correlation scores and serological indexes in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.0% and 97.5%, respectively, and there were differences between two groups (P<0.05). After treatment, vaginal bleeding score, insomnia dream score, waist and knee acid soft score, fatigue and fatigue score, and five upset heat score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the clinical symptom scores in the treatment group were significantly lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, PBAC score, SAS score, and SDS score in two groups were significantly decreased, but GQOL-74 score was significantly increased, and there were differences in the same group (P<0.05). After treatment, the PBAC score, SAS score, and SDS score in the treatment group were significantly lower than those in the control group, and GQOL-74 score was higher than that in the control group, and there were differences between two groups (P<0.05). After treatment, Ang-2 and E₂ in two groups were significantly decreased, but VEGF and HB were significantly increased, and there were differences in the same group (P<0.05). After treatment, Ang-2 and E₂ in the treatment group were significantly lower than those in the control group, and VEGF and HB were higher than that in the control group, and there were differences between two groups (P<0.05). Conclusion Yifu Zhixue Pills combined with Progesterone Capsules has significant effect in treatment of anovulatory dysfunctional uterine bleeding, and can effectively improve the clinical symptoms, and also can improve the menstrual condition and anxiety state, and improve the life quality of patients, which has a certain clinical application value.