目的 探讨一清片联合西地碘含片治疗重度慢性牙周炎的临床疗效。方法 选择2018年1月-2018年10月首都医科大学附属北京潞河医院收治的128例重度慢性牙周炎患者作为研究对象，所有患者按照治疗方式差异分为对照组和治疗组，每组各64例。对照组患者含服西地碘含片，1片/次，3次/d。治疗组在对照组治疗基础上口服一清片，4片/次，3~4次/d。两组均连续治疗3个月。观察两组的临床疗效，比较两组的牙周指标、炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为70.31%、90.63%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者龈沟出血指数（SBI）、附着丧失（AL）、菌斑指数（PLI）、牙周袋深度（PD）、牙龈指数（GI）均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组牙周指标均明显于低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）水平均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组炎性因子水平明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 一清片联合西地碘含片治疗重度慢性牙周炎具有较好的临床疗效，能缓解患者临床症状，改善患者牙周指标，降低患者炎症反应，具有一定的临床推广。

Objective To investigate the efficacy of Yiqing Tablets combined with Cydiodine Buccal Tablets in treatment of severe chronic periodontitis. Methods Patients (128 cases) with severe chronic periodontitis in Beijing Luhe Hospital Affiliated to Capital Medical University from January 2018 to October 2018 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 64 cases. Patients in the control group were po administered with Cydiodine Buccal Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Yiqing Tablets on the basis of the control group, 4 tablets/time, three to four times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and periodontal parameters and inflammatory factors levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.31% and 90.63%, respectively, and there was difference between two groups (P<0.05). After treatment, SBI, AL, PLI, PD, and GI in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the periodontal parameters in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-6, IL-1β, CRP, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Yiqing Tablets combined with Cydiodine Buccal Tablets has clinical curative effect in treatment of severe chronic periodontitis, can alleviate the clinical symptoms, improve the periodontal index, and reduce the inflammatory reaction of patients, which has a certain clinical application value.