目的 研究润燥止痒胶囊联合丁酸氢化可的松乳膏治疗慢性湿疹的临床疗效。方法 选取2017年1月-2019年1月海安市人民医院收治的100例慢性湿疹患者为研究对象，将所有患者采用随机数字表法分为对照组和治疗组，每组各50例。对照组患者给予丁酸氢化可的松乳膏，取适量本品涂于患处，2次/d；治疗组患者在对照组治疗的基础上口服润燥止痒胶囊，4粒/次，3次/d。两组患者连续治疗4周。观察两组的临床疗效，比较两组的皮肤生理功能、临床症状评分、复发情况。结果 治疗后，对照组和治疗组的总有效率分别为81.67%、95.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者经表皮水份流失（TEWL）水平明显降低，皮肤油脂（SC）和角质层含水量（WCSC）水平明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患者皮肤生理功能指标水平明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者临床症状评分、严重度指数（EASI）评分、皮损面积评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组患者临床症状评分、EASI评分、皮损面积评分明显低于对照组，两组比较差异有统计学意义（P<0.05）。停药后8周，对照组和治疗组复发率分别为16.00%、4.00%，两组复发率比较差异有统计学意义（P<0.05）。结论 润燥止痒胶囊联合丁酸氢化可的松乳膏治疗慢性湿疹具有较好的临床疗效，能够改善临床症状，降低复发率，具有一定的临床推广应用价值。

Objective To study the efficacy of Runzao Zhiyang Capsules combined with Hydrocortisone Butyrate Cream in treatment of chronic eczema. Methods Patients (100 cases) with chronic eczema in Haian People's Hospital from January 2017 to January 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were given Hydrocortisone Butyrate Cream, applied appropriate amount to the affected area, twice daily. Patients in the treatment group were po administered with Runzao Zhiyang Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and skin physiological function, clinical symptom scores, and recurrence in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.67% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TEWL in two groups were significantly decreased, but the levels of SC and WCSC in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the skin physiological function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, clinical symptom scores, EASI scores, and skin lesion area scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After withdrawal for 8 weeks, the recurrence rates in the control and treatment groups were 16.00% and 4.00%, respectively, and there was difference between two groups (P<0.05). Conclusion Runzao Zhiyang Capsules combined with Hydrocortisone Butyrate Cream has clinical curative effect in treatment of chronic eczema, can improve the clinical symptoms, and reduce the recurrence rate, which has a certain clinical application value.