目的 探讨接骨续筋胶囊联合复方骨肽注射液治疗四肢骨折的临床效果。方法 选取2016年6月-2018年8月北京燕化医院收治的134例四肢骨折患者，随机分成对照组和治疗组，每组各67例。对照组静脉滴注复方骨肽注射液，10 mL加入250 mL生理盐水均匀混合后给药，1次/d，连用3周后停药1周（此为1个周期），连用2个周期（共8周）。治疗组在对照组治疗基础上口服接骨续筋胶囊，4粒/次，3次/d。治疗8周后观察两组疗效。比较两组骨折临床愈合时间、相关症状评分、骨痂骨密度值和相关生长因子水平的变化。结果 治疗后，对照组和治疗组的总有效率分别是85.1%、95.5%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组疼痛评分、肿胀评分、瘀斑评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些症状评分显著低于对照组，两组比较差异有统计学意义（P<0.05）。治疗组肱骨干骨折临床愈合时间、尺桡骨干骨折临床愈合时间、股骨干骨折临床愈合时间、胫骨干骨折临床愈合时间均显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清转化生长因子（TGF）-β1、碱性成纤维生长因子（bFGF）、骨形态发生蛋白（BMP）-2水平均显著增加，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些相关生长因子水平显著高于对照组，两组比较差异有统计学意义（P<0.05）。治疗组治疗4、8周时骨痂骨密度值均显著高于对照组，两组比较差异有统计学意义（P<0.05）。结论 接骨续筋胶囊联合复方骨肽注射液治疗四肢骨折可明显减轻患者症状，缩短骨折愈合时间，增强骨折愈合强度，上调骨相关生长因子表达，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jiegu Xujin Capsules combined with Compound Ossotide Injection in treatment of limbs fracture. Methods Patients (134 cases) with limbs fracture in Beijing Yanhua Hospital in June 2016 to 2018 August were randomly divided into control (67 cases) and treatment (67 cases) groups. Patients in the control group were iv administered with Compound Ossotide Injection, 10 mL added into 250 mL normal saline, once daily. After continuous use for 3 weeks, the drug was discontinued for 1 week (this was 1 cycle) and for 2 cycle s (8 weeks in total). Patients in the treatment group were po administered with Jiegu Xujin Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the fracture clinical healing time, related symptom scores, callus bone density value and related growth factor levels in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 85.1% and 95.5%, respectively, and there were differences between two groups (P<0.05). After treatment, pain score, swelling score, and petechial score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the related symptom scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). The clinical healing time of humeral shaft fractures, ulnar and radial shaft fractures, femoral shaft fractures and tibial shaft fractures in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, TGF-β1, bFGF, and BMP-2 in two groups were treatment group were higher than those in the control group, and there were differences between two groups (P<0.05). Callus BMD of the treatment group was significantly higher than that of the control group at 4 and 8 weeks, and there were differences between two groups (P<0.05). Conclusion Jiegu Xujin Capsules combined with Compound Ossotide Injection in treatment of limbs fracture can significantly reduced symptoms, and can shorten fracture healing time, and enhanced fracture healing intensity, up-regulated expression of bone-related growth factors, which has a certain clinical application value.