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[摘要]
目的 探讨复方杜仲健骨颗粒联合硫酸氨基葡萄糖胶囊治疗膝骨关节炎的临床疗效。方法 选取2017年2月-2018年2月在北京市东城区第一人民医院诊治的膝骨关节炎患者98例,根据挂号的奇偶性分为对照组(49例)和治疗组(49例)。对照组口服硫酸氨基葡萄糖胶囊,0.628 g/次,3次/d;治疗组在对照组的基础上口服复方杜仲健骨颗粒,12 g/次,3次/d。两组患者经4周治疗。观察两组患者临床疗效,同时比较治疗前后两组患者WOMAC、VAS、LKSS和ISOA评分及血清超敏C反应蛋白(hs-CRP)、软骨寡聚基质蛋白(COMP)、白细胞介素-17(IL-17)、基质金属蛋白酶-3(MMP-3)、环氧化酶-2(COX-2)水平。结果 治疗后,对照组临床有效率为81.63%,显著低于治疗组的95.92%,两组比较差异有统计学意义(P<0.05)。经治疗,两组患者WOMAC评分、VAS评分、ISOA评分均明显下降(P<0.05),LKSS评分明显升高(P<0.05),且治疗组患者这些评分明显好于对照组(P<0.05)。经治疗,两组血清hs-CRP、COMP、IL-17、MMP-3、COX-2水平均显著降低(P<0.05),且治疗组患者这些血清学指标明显低于对照组(P<0.05)。结论 复方杜仲健骨颗粒联合硫酸氨基葡萄糖胶囊治疗膝骨关节炎患者可改善患者膝关节功能,降低机体hs-CRP、COMP、IL-17、MMP-3、COX-2水平。
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[Abstract]
Objective To explore the clinical effect of Compound Duzhong Jianggu Granules combined with glucosamine sulfate in treatment of knee osteoarthritis. Methods Patients (98 cases) with knee osteoarthritis in Beijing Dongcheng District First People's Hospital from February 2017 to February 2018 were divided into control (49 cases) and treatment (49 cases) groups based on registration numbers. Patients in the control group were po administered with Glucosamine Sulfate Capsules, 0.628 g/time,three times daily. Patients in the treatment group were po administered with Compound Duzhong Jianggu Granules on the basis of the control group, 12 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the WOMAC, VAS, LKSS and ISOA scores, and serum levels of hs-CRP, COMP, IL-17, MMP-3, and COX-2 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.63%, which was significantly lower than 95.92% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the WOMAC, VAS and ISOA scores in two groups were significantly decreased (P<0.05), but LKSS scores were significantly increased (P<0.05), and these scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the serum levels of hs-CRP, COMP, IL-17, MMP-3, and COX-2 in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Compound Duzhong Jianggu Granules combined with glucosamine sulfate in treatment of knee osteoarthritis can improve knee joint function, and reduce the serum hs-CRP, COMP, IL-17, MMP-3, COX-2 levels.
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