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[摘要]
目的 观察胃肠安丸联合美沙拉秦治疗溃疡性结肠炎的临床疗效。方法 选取河南省第二人民医院2018年1月-2018年12月接诊的溃疡性结肠炎患者106例,随机分为对照组和治疗组,每组各53例。对照组口服美沙拉秦肠溶片,1 g/次,3次/d;治疗组在对照组的基础上口服胃肠安丸,4丸/次,3次/d。两组患者均治疗12周。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状积分、腹泻次数及血清白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平。结果 治疗后,对照组和治疗组临床有效率分别为73.58%和90.57%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者腹泻、脓血便、腹痛等主要症状积分均明显降低(P<0.05),两组腹泻次数也显著减少(P<0.05),且治疗组患者临床症状积分以及腹泻次数明显少于对照组(P<0.05)。治疗后,两组患者血清IL-1β、IL-6、TNF-α、CRP水平明显降低(P<0.05),且治疗组患者IL-1β、IL-6、TNF-α、CRP水平明显低于对照组(P<0.05)。结论 胃肠安丸联合美沙拉秦肠溶片治疗溃疡性结肠炎临床疗效确切,症状改善明显,炎症因子明显下降。
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[Abstract]
Objective To observe the clinical efficacy of Weichang'an Pills combined with mesalazine in treatment of ulcerative colitis. Methods Patients (106 cases) with ulcerative colitis in Henan NO.2 Provincial People's Hospital from January 2018 to December 2018 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Mesalazine Enteric-coated Tablets, 1 g/time, three times daily. Patients in the treatment group were po administered with Weichang'an Pills on the basis of the control group, 4 pills/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, frequency of diarrhea, and serum levels of IL-1β, IL-6, TNF-α, and CRP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 73.58% and 90.57%, respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores of diarrhea, bloody stool, and abdominal pain in two groups were significantly decreased (P<0.05), the frequency of diarrhea was significantly decreased (P<0.05), and the clinical symptom scores and frequency of diarrhea in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of IL-1β, IL-6, TNF-α, and CRP in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion WeichangAn Pills combined with mesalazine has definite clinical effect in treatment of ulcerative colitis, can improve the symptoms obviously and decrease inflammatory factors.
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