目的 探讨愈美颗粒联合阿莫西林克拉维酸钾治疗小儿急性支气管炎的临床疗效。方法 选取2018年3月-2019年3月在延安大学咸阳医院治疗的急性支气管炎患儿94例，根据用药的差别分为对照组（47例）和治疗组（47例）。对照组口服阿莫西林克拉维酸钾颗粒，20 mg/kg，1次/8 h；治疗组在对照组基础上口服愈美颗粒，1~6岁，0.5包/次，7~12岁，1包/次，3次/d。两组均经10 d治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状改善时间，血清超敏C反应蛋白（hs-CRP）、白细胞介素-1β（IL-1β）、IL-13、IL-17、可溶性髓系细胞触发受体-1（sTREM-1）和半胱氨酰白三烯（CysLTs）水平及肺功能。结果 治疗后，对照组临床有效率为80.85%，显著低于治疗组的97.87%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者的发热、咳嗽咳痰、喘息、肺部啰音等症状消失时间均明显早于对照组（P<0.05）。治疗后，两组患者血清hs-CRP、IL-1β、IL-13、IL-17、sTREM-1、CysLTs水平均明显下降（P<0.05），且治疗组血清指标水平明显低于对照组（P<0.05）。治疗后，两组患者RR、Ti/Te均明显降低（P<0.05），而VT、tPTEF/tE均明显升高（P<0.05），且治疗后治疗组患者肺功能明显好于对照组（P<0.05）。结论 愈美颗粒联合阿莫西林克拉维酸钾治疗急性支气管炎可有效改善患儿临床症状，降低机体炎症反应，促进肺功能改善。

Objective To explore the clinical efficacy of Yumei Granules combined with amoxicillin and clavulanate potassium in treatment of acute bronchitis in children. Methods Children (94 cases) with acute bronchitis in Xianyang Hospital of Yan'an University from March 2018 to March 2019 were divided into control (47 cases) and treatment (47 cases) groups based on different treatments. Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Granules, 20 mg/kg, once every 8 h. Children in the treatment group were po administered with Yumei Granules on the basis of the control group, 0.5 bag/time for 1-6 years old, 1 bag/time for 7-12 years old, three times daily. Children in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the symptoms improvement time, serum levels of hs-CRP, IL-1β IL-13, IL-17, sTREM-1 and CysLTs, and lung function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.85%, which was significantly lower than 97.87% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the symptoms improvement time of fever, cough and expectoration, wheezing, and lung rales in the treatment group were significantly earlier than those in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-1β IL-13, IL-17, sTREM-1, and CysLTs in two groups were significantly decreased (P<0.05), and the serological indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the RR and Ti/Te in two groups were significantly decreased (P<0.05), but VT and tPTEF/tE were significantly increased (P<0.05), and the lung function in the treatment group were significantly better than that in the control group (P<0.05). Conclusion Yumei Granules combined with amoxicillin and clavulanate potassium in treatment of acute bronchitis in children can effectively improve the clinical symptoms, reduce the inflammatory response, and promote the improvement of lung function.