目的 研究清心滚痰丸联合利培酮片治疗精神分裂症的临床疗效。方法 选择2015年6月-2018年8月在合肥市第四人民医院接受治疗的108例精神分裂症患者作为研究对象，所有患者依据用药方式不同分对照组和治疗组，每组各54例。对照组口服利培酮片，起始剂量1 mg/次，2次/d，第二周逐渐加量至4 mg/次，2次/d。治疗组在对照组治疗的基础上口服清心滚痰丸，6 g/次，1次/d。两组均连续治疗8周。观察两组的临床疗效，比较两组的临床症状评分、血清指标水平、不良反应。结果 治疗后，对照组和治疗组的总有效率分别为77.78%、94.44%，两组比较差异有统计学意义（P<0.05）。治疗后，两组阳性和阴性症状量表（PANSS）评分、汉密尔顿抑郁量表（HAMD）评分均明显降低，生活质量综合评定量表（GQOLI-74）评分明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组临床症状评分明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组神经元特异性烯醇化酶（NSE）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组血清指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组TESS评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）结论 清心滚痰丸联合利培酮片治疗精神分裂症具有较好的临床疗效，可改善临床症状、抑郁程度、生活质量，降低炎症反应，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical study of Qingxin Guntan Pills combined with Risperidone Tablets in treatment of schizophrenia. Methods Patients (84 cases) with schizophrenia in The Fourth People's Hospital of Hefei from June 2015 to August 2018 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 54 cases. Patients in the control group were po administered with Risperidone Tablets, starting dosage 1 mg/time, twice daily, and gradually increased from the second week to 4 mg/time, twice daily. Patients in the treatment group were po administered with Qingxin Guntan Pills on the basis of the control group, 6 g/time, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores, the level of serum indicators, and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 94.44%, respectively, and there was difference between two groups (P<0.05). After treatment, PANSS scores and HAMD scores in two groups were significantly decreased, but GQOLI-74 scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptom scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of NSE, IL-1β, IL-6 and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the level of serum indicators in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the TESS score in the treatment group were significantly lower than that in the control group, and there was difference between two groups (P<0.05). Conclusion Qingxin Guntan Pills combined with Risperidone Tablets has clinical curative effect in treatment of schizophrenia, can improve clinical symptoms, depression and quality of life, and reduce inflammation, with good safety, which has a certain clinical application value.