目的 探讨硝呋太尔联合盐酸特比萘芬阴道泡腾片治疗念珠菌阴道炎的临床疗效。方法 选取2013年2月-2017年2月在山东省医学科学院附属医院治疗的念珠菌阴道炎患者200例，随机分为对照组和治疗组，每组各100例。对照组患者给予盐酸特比萘芬阴道泡腾片，睡前1片放入阴道后穹窿处。治疗组在对照组的基础上口服硝呋太尔片，1片/次，3次/d。两组患者均治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状消失时间、阴道灌洗液中细胞因子水平和不同时间复发率。结果 治疗后，对照组临床有效率为72%，显著低于治疗组的89%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者外阴瘙痒、外阴阴道疼痛、白带异常及外阴阴道充血、红肿症状平均消失时间比对照组明显缩短（P<0.05）。治疗后，两组患者阴道灌洗液中TNF-α、IL-6、IL-1β水平显著降低（P<0.05），且治疗组患者阴道灌洗液中TNF-α、IL-6、IL-1β水平明显低于对照组（P<0.05）。治疗组患者4、8、12周后复发率分别为2%、5%、8%，均显著低于同一时间段的对照组患者复发率，两组比较差异比较均具有统计学意义（P<0.05）。结论 硝呋太尔联合盐酸特比萘芬阴道泡腾片治疗念珠菌阴道炎临床疗效显著，能有效改善患处的炎症反应，降低复发率。

Objective To explore the clinical efficacy of nifuratel combined with Terbinafine Hydrochloride Vaginal Effervescent Tablets in treatment of candidal vaginitis. Methods Patients (200 cases) with candidal vaginitis in Affiliated Hospital of Shandong Academy of Medical Sciences from February 2013 to February 2017 were randomly divided into control and treatment groups, and each group had 100 cases. Patients in the control group were administered with Terbinafine Hydrochloride Vaginal Effervescent Tablets, put 1 tablet into the posterior vaginal fornix before bed. Patients in the treatment group were po administered with Nifuratel Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms disappearance time, the cytokine levels in vaginal lavage fluid and recurrence rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72%, which was significantly lower than 89% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the clinical symptoms disappearance time of vulvar pruritus, vulvovaginal pain, abnormal leucorrhea, vulvovaginal congestion and swelling in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the TNF-α, IL-6, IL-1β levels in vaginal lavage fluid in two groups were significantly decreased (P<0.05). And the cytokine levels in the treatment group was significantly lower than those in the control group (P<0.05). After treatment, the recurrence rate of 4, 8, and 12 weeks was 2%, 5%, and 8% respectively in the treatment group, which were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Nifuratel combined with Terbinafine Hydrochloride Vaginal Effervescent Tablets has good clinical efficacy in treatment of candidal vaginitis, can effectively improve the inflammatory reaction and reduce the recurrence rate.