目的 探讨荆肤止痒颗粒联合盐酸左西替利嗪治疗儿童慢性荨麻疹的临床疗效。方法 选取2018年5月-2019年2月在绵阳市妇幼保健院诊治的慢性荨麻疹患儿94例，根据用药的差别分为对照组（47例）和治疗组（47例）。对照组餐前30 min口服盐酸左西替利嗪口服溶液，2~6岁，1次/d，5 mL/次；6岁以上，1次/d，10 mL/次。治疗组在对照组基础上口服荆肤止痒颗粒，1~2岁，3次/d，1.5 g/次；3~5岁，2次/d，3 g/次；6~14岁，3次/d，3 g/次。两组患儿均经6 d治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分及血清白细胞介素-4（IL-4）、IL-13、IL-17、IL-18、肿瘤坏死因子-α（TNF-α）和可溶性血管细胞黏附分子-1（sVCAM-1）水平。结果 治疗后，对照组和治疗组临床有效率分别为80.85%和97.87%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者瘙痒程度、风团数目、风团大小等症状积分均显著下降（P<0.05），且治疗组患者临床症状积分明显低于对照组患者（P<0.05）。经治疗，两组患者血清IL-4、IL-13、IL-17、IL-18、TNF-α、sVCAM-1水平均显著下降（P<0.05），且治疗组患者这些血清学指标明显低于对照组（P<0.05）。结论 荆肤止痒颗粒联合盐酸左西替利嗪口服溶液治疗儿童慢性荨麻疹可有效改善患儿临床症状，降低机体炎症因子水平，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Jingfu Zhiyang Granule combined with levocetirizine in treatment of chronic urticaria in children. Methods Children (94 cases) with chronic urticaria in Mianyang Maternal and Child Health-Care Hospital from May 2018 to February 2019 were divided into control (47 cases) and treatment (47 cases) groups based on different treatments. Children in the control group were po administered with Levocetirizine Hydrochloride Oral Solution 30 min before meals, 5 mL/time for 2-6 years old children, 10 mL/time for more than 6 years old, once daily. Children in the treatment group were po administered with Jingfu Zhiyang Granule on the basis of the control group, 1.5 g/time for 1-2 years old children, three times daily, 3 g/time for 3-5 years old children, twice daily, 3 g/time for 6-14 years old children, three times daily. Children in two groups were treated for 6 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, and serum levels of IL-4, IL-13, IL-17, IL-18, TNF-α and sVCAM-1 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.85% and 97.87% respectively, and there were differences between two groups (P<0.05). After treatment, the symptom scores of itching, number and size of wind groups in two groups were significantly decreased (P<0.05), and the symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of IL-4, IL-13, IL-17, IL-18, TNF-α, and sVCAM-1 in two groups were significantly decreased (P<0.05), and these serological indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jingfu Zhiyang Granule combined with levocetirizine in treatment of chronic urticaria in children can effectively improve the clinical symptoms, reduce the level of inflammatory factors, which has a certain clinical application value.