目的 探讨九味镇心颗粒联合氟伏沙明治疗老年期抑郁症的临床效果。方法 选取2017年1月-2018年9月成都市第三人民医院收治的88例老年期抑郁症患者，随机分为对照组和治疗组，每组各44例。对照组口服马来酸氟伏沙明片，100 mg/次，1次/d。治疗组在对照组基础上口服九味镇心颗粒，1袋/次，3次/d。两组连续治疗8周。观察两组的临床疗效，比较两组治疗前后17项汉密尔顿抑郁量表（HDRS-17）评分、汉密顿焦虑量表（HAMA）评分、匹兹堡睡眠质量指数（PSQI）评分、自杀意念自评量表（SIOSS）评分、家庭负担访谈问卷（FEIS）评分及36项健康调查简表（SF-36）评分变化。结果 对照组和治疗组的总有效率分别是81.8%、95.5%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组HDRS-17评分、HAMA评分和PSQI评分较治疗前均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组SIOSS中各因子（绝望、乐观、睡眠、掩饰）评分及总分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组SIOSS评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组FEIS中各因子评分及总分较治疗前均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组FEIS中各因子评分及总分均高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组SF-36中PCS评分、MCS评分及总分均较治疗前显著增加，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组PCS评分、MCS评分及总分均显著高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 九味镇心颗粒联合氟伏沙明治疗老年期抑郁症具有较好的临床疗效，能明显缓解患者病情，改善睡眠，降低自杀风险，减轻照料者的家庭负担，提高生活质量，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Jiuwei Zhenxin Granules combined with fluvoxamine in treatment of senile depression. Methods Patients (88 cases) with senile depression in Chengdu Third People's Hospital from January 2017 to September 2018 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Fluvoxamine Maleate Tablets, 100 mg/time, once daily. Patients in the treatment group were po administered with Jiuwei Zhenxin Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of HDRS-17 score, HAMA score, PSQI score, SIOSS score, FEIS score, and SF-36 score in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.8% and 95.5%, respectively, and there were differences between two groups (P<0.05). After treatment, HDRS-17 score, HAMA score and PSQI score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, factors (despair, optimism, sleep, and cover-up) of SIOSS scores and total score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, SIOSS scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, each factor of FEIS scores and total score in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, FEIS scores in the treatment group were higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, PCS score, MCS score and total score of SF-36 in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, PCS score, MCS score and total score in the treatment group were higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Jiuwei Zhenxin Granules combined with fluvoxamine has significant effect in treatment of senile depression, and can significantly alleviate the patients' condition, and can improve sleep quality, and also can reduce the suicide risk, and can reduce the burden on the family of the caregiver, and can improve life quality, which has a certain clinical application value.