目的 探讨清热散结胶囊联合头孢克肟治疗急性支气管炎患儿的临床疗效。方法 选取2018年2月-2018年11月在成都市第三人民医院治疗的急性支气管炎患儿118例，根据用药的差别分为对照组（59例）和治疗组（59例）。对照组口服头孢克肟分散片，0.1 g/次，2次/d；治疗组在对照组基础上口服清热散结胶囊，1.75 g/次，3次/d。两组均治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状改善时间和炎症因子水平。结果 治疗后，对照组和治疗组临床有效率分别为81.36%和96.61%，两组比较差异具有统计学意义（P<0.05）。经治疗，治疗组患者体温、咳嗽和肺部啰音复常时间均明显早于对照组，两组比较差异具有统计学意义（P<0.05）。经治疗，两组患者血清超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、半胱氨酰白三烯（CysLTs）、可溶性髓系细胞触发因子-1（sTREM-1）、白细胞介素-6（IL-6）水平显著降低（P<0.05），且治疗组患者hs-CRP、TNF-α、CysLTs、sTREM-1、IL-6水平明显低于对照组患者（P<0.05）。结论 清热散结胶囊联合头孢克肟治疗急性支气管炎患儿可有效改善患者临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Qingre Sanjie Capsules combined with cefixime in treatment of acute bronchitis. Methods Patients (118 cases) with acute bronchitis in Chengdu Third People's Hospital from February 2018 to November 2018 were divided into control (59 cases) and treatment (59 cases) groups based on different treatments. Patients in the control group were po administered with Cefixime Dispersible Tablets, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Qingre Sanjie Capsules on the basis of the control group, 1.75 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, the inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.36% and 96.61%, respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of temperature, cough and lung rales in the treatment group was significantly earlier than that in the control group, with significant difference between two groups (P<0.05). After treatment, the serum hs-CRP, TNF-α, CysLTs, sTREM-1 and IL-6 levels in two groups were significantly decreased (P<0.05), and the inflammatory factors levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qingre Sanjie Capsules combined with cefixime in treatment of acute bronchitis can effectively improve the clinical symptoms, reduce the inflammatory response, which has a certain clinical application value.

R974

四川省卫生和计划生育科研课题（17PJ381）