目的 探讨复方斑蝥胶囊联合DP方案（注射用顺铂联合多西他赛注射液）治疗晚期卵巢癌的临床疗效。方法 选取2012年1月—2014年1月在乐山市人民医院接受治疗的晚期卵巢癌患者114例为研究对象，采用随机数字表法将所有患者分为对照组和治疗组，每组各57例。对照组给予DP方案化疗：第1天静脉滴注多西他赛注射液75 mg/m²；第1～3天静脉滴注注射用顺铂30 mg/m²。治疗组在对照组治疗的基础上口服复方斑蝥胶囊，3粒/次，2次/d。3周为1个周期，两组患者连续治疗4个周期。观察两组的临床疗效，比较两组的生活质量和毒副作用。结果 治疗后，对照组和治疗组的疾病控制率分别为45.6%、68.4%，客观缓解率分别为63.2%、77.2%，两组临床疗效比较差异有统计学意义（P<0.05）。治疗后，两组生理状况评分、情感状况评分和附加关注评分明显下降，功能状况评分、社会状况评分明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组生活质量评分明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，治疗组肝功能损伤、皮疹、白细胞计数下降、胃肠道反应和周围神经病变的发生率均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组1年生存率、3年生存率、无进展生存期（PFS）和总生存时间（OS）均明显高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 复方斑蝥胶囊联合DP方案治疗晚期卵巢癌具有较好的临床疗效，可改善患者生活质量，提高生存率，延长PFS和OS，具有一定临床推广应用价值。

Objective To observe the effects of Compound Banmao Capsules combined with DP regiment (Cisplatin for injection combined with Docetaxel Injection) in treatment of advanced ovarian cancer. Methods Patients (114 cases) with advanced ovarian cancer in the People's Hospital of Leshan from January 2012 to January 2014 were randomly divided into control and treatment groups, and each group had 57 cases. Patients in the control group were given DP regiment, at the first day, intravenous drip of Docetaxel Injection 75 mg/m², and in the first to second day, intravenous drip of Cisplatin for injection 30 mg/m². Patients in the treatment group were po administered with Compound Banmao Capsules on the basis of the control group, 3 grains/time, twice daily. As 3 weeks for 1 cycle, patients in two groups were treated for 4 cycles. After treatment, the clinical efficacies were evaluated, and quality of life and toxic and side efficacies in two groups were compared. Results After treatment, the disease control rates in the control and treatment groups were 45.6% and 68.4%, respectively, and the objective remission rates in the control and treatment groups were 63.2% and 77.2%, respectively, and there was difference between two groups (P < 0.05). After treatment, physical condition score, emotional status score, and additional attention score in two groups were significantly decreased, but functional status score and social status score in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the quality of life scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). During the period of treatment, the incidence rate of liver function impairment, rash, white blood cell count decline, gastrointestinal reaction, and peripheral neuropathy in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P < 0.05). After treatment, 1 year survival rate, 3 year survival rate, PFS, and OS in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P < 0.05). Conclusion Compound Banmao Capsules combined with DP regiment has clinical curative effect in treatment of advanced ovarian cancer, can improve the quality of life, increase the survival rate, prolong PFS and OS, which has a certain clinical application value.