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[摘要]
目的 探讨龙血竭片联合诺氟沙星治疗宫颈糜烂的临床效果。方法 选取2015年1月—2018年1月南开大学附属医院(天津市第四医院)收治的92例宫颈糜烂患者,随机分成随机分为对照组(46例)和治疗组(46例)。对照组患者口服诺氟沙星胶囊,4粒/次,2次/d,于早晚餐前30 min服用。治疗组在对照组的基础上口服龙血竭片,4片/次,3次/d,三餐前服用。两组均连续治疗21 d。治疗后评价两组患者临床疗效,同时比较治疗前后两组患者各主症积分及总分、各相关体征评分及总分变化和复发情况。结果 治疗后,治疗组的总有效率为93.5%,明显高于对照组的78.3%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组腰骶胀痛和带下异常(量多、色黄、气臭)积分及总分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组主症积分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组糜烂面积、炎症程度、阴道清洁度评分及总分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组相关体征评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。对照组和治疗组的复发率分别为17.4%、2.2%,两组比较差异具有统计学意义(P<0.05)。结论 龙血竭片联合诺氟沙星治疗宫颈糜烂疗效确切,能明显改善患者症状,缩小糜烂面积,缓解局部炎症,降低复发风险,患者耐受性好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Longxuejie Tablets combined with norfloxacin in treatment of cervical erosion. Methods Patients (92 cases) with cervical erosion in Affiliated Hospital of Nankai University (Tianjin Fourth Hospital) from January 2015 to January 2018 were randomly divided into control group (46 cases) and treatment group (46 cases). Patients in the control group were po administered with Norfloxacin Capsules, 4 grains/time, twice daily, 30 min before dinner. Patients in the treatment group were po administered with Longxuejie Tablets on the basis of the control group, 4 tablets/time, three times daily, before meals. Patients in two groups were treated for 21 d. After treatment, clinical efficacy was evaluated, and the scores and total scores of the main symptoms before and after treatment, the scores of the relevant physical signs and the changes in total scores, and recurrences were compared. Results After treatment, the clinical efficacy in the treatment group was 93.5%, which was significantly higher than 78.3% in the control group, and there were differences between two groups (P < 0.05). After treatment, the scores of lumbosacral pain and subdural abnormalities (quantity, yellowness, and odor) were significantly decreased, and there were differences between two groups (P < 0.05). And the main symptoms scores in the treatment group were obviously lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of erosion area, degree of inflammation, and vaginal cleanliness were significantly decreased, and there were differences between two groups (P < 0.05). And the relevant physical signs scores in the treatment group were obviously lower than those in the control group, with significant difference between two groups (P < 0.05). The recurrence rate in the control and treatment groups were 17.4% and 2.2%, respectively, and there were differences between two groups (P < 0.05). Conclusion Longxuejie Tablets combined with norfloxacin has good effect in treatment of cervical erosion, and can improve the clinical symptoms, reduce erosion area, local inflammation, and recurrent risk with good tolerance, which has a certain clinical application value.
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