目的 探讨应用大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛的临床效果。方法 选取2016年1月-2017年12月汕头市潮阳区大峰医院收治的不稳定型心绞痛患者126例，随机分成对照组（63例）与治疗组（63例）。对照组静脉滴注注射用丹参多酚酸盐，200 mg加入5%葡萄糖注射液250 mL，1次/d。治疗组在对照组的基础上静脉滴注大株红景天注射液，10 mL加入5%葡萄糖液250 mL，1次/d。两组均连续治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者低/高密度脂蛋白比值（LDL/HDL）比值、外周血中性粒细胞/淋巴细胞比值（NLR）、内皮细胞微粒（EMPs）、血液流变学指标和血清学指标。结果 治疗后，对照组和治疗组临床总有效率分别为73.0%和87.3%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清LDL/HDL比值和外周血NLR、EMPs值均显著减少（P<0.01），且治疗后治疗组上述指标下降更明显（P<0.01）。治疗后两组患者全血黏度（WBV）、纤维蛋白原（FIB）、红细胞比容（Hct）值均显著降低（P<0.01），且治疗后治疗组血流变指标明显低于对照组（P<0.01）。治疗后，两组血清白细胞介素（IL）-2、IL-8、内脏脂肪素（visfatin）和基质金属蛋白酶（MMP）-9浓度较治疗前均明显降低（P<0.05），且治疗组上述血清学指标明显低于对照组（P<0.05）。结论 大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛可有效缓解患者症状，改善血液流变状态，保护血管内皮功能，增强斑块稳定性。

Objective To investigate the clinical effect of Sofren Injection combined with salvianolate in treatment of unstable angina pectoris. Methods Patients (126 cases) with unstable angina pectoris in Dafeng Hospital of Chaoyang District in Shantou from January 2016 to December 2017 were randomly divided into control (63 cases) and treatment (63 cases) groups. Patients in the control group were iv administered with Salvianolate for injection, 200 mg added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were iv administered with Sofren Injection on the basis of the control group, 10 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and LDL/HDL, NLR, EMPs, the hemorheological and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 73.0% and 87.3% respectively, and there were differences between two groups (P<0.05). After treatment, the LDL/HDL, NLR and EMPs in two groups were significantly decreased (P<0.01), and these indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.01). After treatment, the WBV, FIB and Hct in two groups were significantly decreased (P<0.01), and the hemorheological indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.01). After treatment, the IL-2, IL-8, visfatin and MMP-9 levels in two groups were significantly decreased (P<0.05), and the serological indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.05). Conclusion Sofren Injection combined with salvianolate in treatment of unstable angina pectoris can effectively alleviate the symptoms, improve hemorrheology state, protect the vascular endothelial function and strengthen the plaque stability.