目的 研究固肠止泻丸联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床疗效。方法 选取2016年2月-2017年2月三二〇一医院收治的溃疡性结肠炎患者86例为研究对象，采用随机数字表法将患者分为对照组和治疗组，每组各43例。对照组饭前口服柳氮磺吡啶肠溶片，1 g/次，3次/d。治疗组在对照组基础上口服固肠止泻丸，5 g/次，3次/d。两组患者均连续治疗6周。观察两组的症状疗效和内镜疗效，比较两组的黏膜愈合情况和时间以及实验室指标。结果 治疗后，对照组和治疗组的症状疗效总有效率分别为79.07%、95.35%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组的内镜疗效总有效率分别为81.40%、95.35%，两组比较差异有统计学意义（P<0.05）。治疗后，两组Baron评分显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组Baron内镜评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组黏膜愈合时间显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组ESR、PLT和D-二聚体水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组实验室指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 固肠止泻丸联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎具有较好的临床疗效，可改善临床症状，降低炎症水平，促进黏膜愈合，具有一定的临床推广应用价值。

Objective To study the clinical effect of Guchang Zhixie Pills combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients (86 cases) with ulcerative colitis in San Er Ling Yi Hospital, from February 2016 to February 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1 g/time, three times daily. Patients in the treatment group were po administered with Guchang Zhixie Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, clinical efficacies of symptom and endoscope were evaluated, and mucous healing condition, mucous healing time, and laboratory indexes in two groups were compared. Results After treatment, the clinical efficacies of symptom in the control and treatment groups were 79.07% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical efficacies of endoscope in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the Baron score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the Baron score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the mucous healing time in the treatment group was significantly shorter than that in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of ESR, PLT, and D-dipolymer in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guchang Zhixie Pills combined with Sulfasalazine Enteric-coated Tablets has clinical curative effect in treatment of ulcerative colitis, can improve clinical symptoms, decrease inflammation level, and promote the healing of mucous membrane, which has a certain clinical application value.