目的 探讨皮肤病血毒片联合盐酸多西环素分散片治疗痤疮的临床疗效。方法 选取2017年2月-2017年7月在监利县人民医院进行诊治的痤疮患者78例临床资料进行回顾性分析，根据用药的不同将所有患者分为对照组和治疗组，每组各39例。对照组口服盐酸多西环素分散片，1片/次，2次/d。治疗组在对照组基础上口服皮肤病血毒片，6片/次，2次/d。两组均连续治疗8周。观察两组的临床疗效，比较两组的红斑评分、色素沉着评分、皮损数量评分、痤疮特异性生活质量量表（Acne-QOL）评分、血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为79.49%、94.87%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组红斑、色素沉着、皮损数量评分显著下降，Acne-QOL评分显著上升，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些评分指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、白细胞介素-17（IL-17）水平明显降低，白细胞介素-10（IL-10）、干扰素-γ（IFN-γ）水平明显升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些血清学指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 皮肤病血毒片联合盐酸多西环素分散片治疗痤疮具有较好的临床疗效，可促进皮肤红斑和色素沉着消退，改善皮损，调节机体炎症反应，提高生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Pifubing Xuedu Tablets combined with Doxycycline Hyclate Dispersible Tablets in treatment of acne. Methods Patients (78 cases) with acne in Jianli County People's Hospital from February 2017 to July 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 39 cases. Patients in the control group were po administered with Doxycycline Hyclate Dispersible Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Pifubing Xuedu Tablets on the basis of the control group, 6 tablets/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and erythema scores, pigmentation scores, skin lesion scores, Acne-QOL scores, and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there was difference between two groups (P < 0.05). After treatment, erythema scores, pigmentation scores, skin lesion scores in two groups were significantly decreased, but the Acne-QOL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the score indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α, IL-8, and IL-17 in two groups were significantly decreased, but the levels of IL-10 and IFN-γ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Pifubing Xuedu Tablets combined with Doxycycline Hyclate Dispersible Tablets has clinical curative effect in treatment of acne, can promote skin erythema and pigmentation subsiding, improve skin lesions, regulate the inflammatory response, and improve the quality of life, which has a certain clinical application value.