目的 探讨润燥止痒胶囊联合盐酸奥洛他定片治疗慢性荨麻疹的临床疗效。方法 选取中国人民解放军第一九五医院2017年2月-2017年8月收治的慢性荨麻疹患者84例，随机分成对照组和治疗组，每组各42例。对照组口服盐酸奥洛他定片，5 mg/次，2次/d；治疗组在对照组基础上口服润燥止痒胶囊，2 g/次，3次/d。两组患者均治疗2周。观察两组患者临床疗效，比较治疗前后两组患者临床症状评分和DLQI评分及血清学指标改善情况。结果 治疗后，对照组临床总有效率为78.57%，显著低于治疗组的95.24%。两组比较差异具有统计学意义（P<0.05）。治疗后，两组临床症状和DLQI评分均显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组比对照组降低的更明显，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清IL-4、IL-10和IL-17水平明显降低，而干扰素-γ（IFN-γ）和IL-18水平明显增高，同组比较差异具有统计学意义（P<0.05）；且治疗组上述血清学指标改善后水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 润燥止痒胶囊联合盐酸奥洛他定片治疗慢性荨麻疹可有效改善患者临床症状，降低机体炎症反应，提高患者生活质量。

Objective To investigate the clinical effect of Runzao Zhiyang Capsules combined with olopatadine in treatment of chronic urticaria. Methods Patients (84 cases) with chronic urticaria in Chinese PLA No.195 Hospital from February 2017 to August 2017 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were po administered with Olopatadine Hydrochloride Tablets, 5 mg/time, twice daily. Patients in the treatment group were po administered with Runzao Zhiyang Capsules on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptoms and DLQI scores, the serological indexes in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control group was 78.57%, which was significantly lower than 95.24% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the clinical symptoms and DLQI scores in two groups were significantly decreased, and there were differences in the same group (P < 0.05). And these scores in the treatment group were significantly lower than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum IL-4, IL-10, and IL-17 levels in two groups were significantly decreased, but IFN-γ and IL-18 were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Runzao Zhiyang Capsules combined with olopatadine in treatment of chronic urticaria can effectively improve the clinical symptoms, reduce inflammation, and improve the quality of life.