目的 探讨妇科千金片联合复方醋酸棉酚片治疗子宫内膜异位症的临床疗效。方法 选取2016年1月-2017年1月定州花张蒙医院收治的子宫内膜异位症患者131例为研究对象，在随机分组的原则下将所有患者分为对照组（65例）和治疗组（66例）。对照组患者口服复方醋酸棉酚片，1片/次，1次/d。治疗组在对照组的基础上口服妇科千金片，6片/次，3次/d。两组患者均连续治疗90 d。观察两组的临床疗效，比较两组的卵巢功能指标、血清癌抗原125（CA125）、视黄醇结合蛋白4（RBP4）、高迁移率族蛋白B1（HMGB1）水平。结果 治疗后，对照组和治疗组的总有效率分别为81.54%、95.45%，复发率分别为13.85%、3.03%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清雌二醇（E₂）、促卵泡成熟激素（FSH）和黄体生成激素（LH）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些卵巢功能指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组癌抗原125（CA125）、视黄醇结合蛋白4（RBP4）、高迁移率族蛋白B1（HMGB1）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 妇科千金片联合复方醋酸棉酚片治疗子宫内膜异位症具有较好的临床疗效，可改善卵巢功能，CA125、RBP4、HMGB1水平，安全性较高，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Fuke Qianjin Tablets combined with Compound Gosspol Acetate Tablets in treatment of endometriosis. Methods Patients (131 cases) with endometriosis in Dingzhou Huazhangmeng Hospital from January 2016 to January 2017 were randomly divided into the control group (65 cases) and the treatment group (66 cases). Patients in the control group were po administered with Compound Gosspol Acetate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Fuke Qianjin Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 90 d. After treatment, the clinical efficacies were evaluated, and ovarian function indexes, CA125, RBP4, and HMGB1 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.54% and 95.45%, respectively, and the recurrence rates in the control and treatment groups were 13.85% and 3.03%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of E₂, FSH, and LH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of CA125, RBP4, and HMGB1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Fuke Qianjin Tablets combined with Compound Gosspol Acetate Tablets has clinical curative effect in treatment of endometriosis, can improve the ovarian function, and decrease the levels of CA125, RBP4, and HMGB1, which has a certain clinical application value.

保定市科技支撑计划项目（14ZF026）