目的 探讨还少胶囊联合戊酸雌二醇片/雌二醇环丙孕酮片复合包装治疗卵巢早衰的临床疗效。方法 选取2015年2月-2017年6月南开大学附属医院（天津市第四医院）收治的132例卵巢早衰患者，随机分为对照组和治疗组，每组各66例。对照组患者给予戊酸雌二醇片/雌二醇环丙孕酮片复合包装，1片/d，连续服用21 d。于撤退性出血第5天重复使用，连续治疗4个月经周期。治疗组在对照组治疗基础上口服还少胶囊，5粒/次，3次/d。有月经来潮者，于月经第5天服用，连续治疗4个月经周期。观察两组的临床疗效，比较两组治疗前后平均卵巢直径（MOD）、窦卵泡个数（AFC）、卵巢动脉收缩期峰值流速（PSV）、子宫内膜厚度、雌二醇（E₂）、卵泡刺激素（FSH）、黄体生成素（LH）、CD³⁺、CD⁴⁺、CD8⁺、CD⁴⁺/CD⁸⁺比值的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、95.45%，两组比较差异有统计学意义（P<0.05）。治疗后，两组MOD、AFC、PSV、子宫内膜厚度、E₂、CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺比值均较治疗前显著增加，但FSH、LH、CD⁸⁺显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组MOD、AFC、PSV、子宫内膜厚度、E₂、CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺比值高于对照组，FSH、LH、CD⁸⁺低于对照组，两组比较差异有统计学意义（P<0.05）。结论 还少胶囊联合戊酸雌二醇片/雌二醇环丙孕酮片复合包装治疗卵巢早衰疗效显著，可有效缓解临床症状，调节性激素水平，促进卵巢功能恢复，增强细胞免疫功能，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Huanshao Capsules combined with Complex Packing Estradiol Valerate Tablets, Estradiol Valerate and Cyproterone Acetate Tablets in treatment of premature ovarian failure. Methods Patients (132 cases) with premature ovarian failure in Affiliated Hospital of Nankai University (the Fourth Hospital of Tianjin) from February 2015 to June 2017 were randomly divided into control (66 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Complex Packing Estradiol Valerate Tablets, Estradiol Valerate and Cyproterone Acetate Tablets for 21 d, 1 tablet/d. And the patients repeated to use in the fifth day of withdrawal hemorrhage, and they were continuously treated for 4 menstrual cycles. Patients in the treatment group were po administered with Huanshao Capsules on the basis of the control group, 5 grains/time, three times daily. If there was menstruation, the patients took Huanshao Capsules on the fifth day of menstruation, and they were continuously treated for 4 menstrual cycles. After treatment, the clinical efficacy was evaluated, and the changes of MOD, AFC, PSV, endometrial thickness, E₂, FSH, LH, CD³⁺, CD⁴⁺, CD⁸⁺, and CD⁴⁺/CD⁸⁺ in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.33% and 95.45%, respectively, and there was difference between two groups (P < 0.05). After treatment, MOD, AFC, PSV, endometrial thickness, E₂, CD³⁺, CD⁴⁺, and CD⁴⁺/CD⁸⁺ in two groups increased significantly, but FSH, LH, and CD⁸⁺ reduced significantly, and the difference was statistically significant in the same group (P < 0.05). After treatment, MOD, AFC, PSV, endometrial thickness, E₂, CD³⁺, CD⁴⁺, and CD⁴⁺/CD⁸⁺ in the treatment group were higher than those in the control group, but FSH, LH, and CD⁸⁺ were lower than those in the control group, and there was difference between two groups (P < 0.05). Conclusions Huanshao Capsules combined with Complex Packing Estradiol Valerate Tablets, Estradiol Valerate and Cyproterone Acetate Tablets has remarkable clinical effect in treatment of premature ovarian failure, and can effectively relieve clinical symptoms, regulate the level of sex hormones, and also can promote the recovery of ovarian function, enhance the cellular immunity function, which has a certain clinical application value.