目的 观察乳酸杆菌活菌联合特比萘芬治疗念珠菌性阴道炎的临床疗效。方法 选取2016年1月-2016年12月在中国人民解放军第四五七医院就诊的念珠菌性阴道炎患者106例，随机分为对照组和治疗组，每组各53例。对照组口服盐酸特比萘芬片，0.25 mg/次，1次/d；治疗组在对照组基础上阴道深部放入阴道用乳杆菌活菌胶囊，1粒/次，1次/晚。两组患者均治疗12周。观察两组患者临床疗效，比较治疗前后两组患者临床症状评分和临床症状体征改善时间。结果 治疗后，对照组临床总有效率为79.25%，显著低于治疗组的92.45%。两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者外阴瘙痒和灼痛感评分均明显降低（P<0.05）；且治疗组上述临床症状评分比对照组更低（P<0.05）。治疗组患者临床症状体征开始改善时间明显短于对照组，两组比较差异具有统计学意义（P<0.05）。结论 乳酸杆菌活菌联合特比萘芬治疗念珠菌性阴道炎疗效显著，可明显改善患者临床症状，不良反应较少，具有一定的临床推广应用价值。

Objective To observe the clinical effect of live lactobacillus combined with terbinafine in treatment of candidal vaginitis. Methods Patients (106 cases) with candidal vaginitis in Chinese PLA No. 457 Hospital from January 2016 to December 2016 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Terbinafine Hydrochloride Tablets, 0.25 mg/time, once daily. Patients in the treatment group were vagina deeply administered with Live Lactobacillus Capsule for vaginal use on the basis of the control group, 1 grain/time, once every night. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom score, the improvement time of clinical symptoms and signs in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.25%, which was significantly lower than 92.45% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the vulva pruritus and pain score in two groups was significantly decreased (P < 0.05), and the score in the treatment group was significantly lower than that in the control group (P < 0.05). After treatment, the improvement time of clinical symptoms and signs in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Live lactobacillus combined with terbinafine has good effect in treatment of candidal vaginitis, can obviously improving the clinical symptoms with less adverse reactions, which has a certain clinical application value.