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[摘要]
目的 探讨黄芪注射液联合螺内酯片治疗糖尿病肾病的临床疗效。方法 选取2015年9月-2017年8月江汉油田总医院收治的糖尿病肾病患者96例作为研究对象,根据随机分组法将所有患者分为对照组和治疗组,每组各48例。对照组口服螺内酯片,20 mg/次,2次/d。治疗组在对照组基础上静脉滴注黄芪注射液,40 mL加入到0.9%氯化钠250 mL中,1次/d。两组均连续治疗1个月。观察两组的临床疗效,比较两组的肾功能指标、炎性因子水平、稳态模型评估-胰岛素抵抗指数(HOMA-IR)。结果 治疗后,对照组和治疗组的总有效率分别为70.8%、91.7%,两组比较差异有统计学意义(P<0.05)。治疗后,两组24 h微量白蛋白(mALB)、尿素氮(BUN)、血肌酐(Scr)、尿白蛋白排泄率(UAER)、β2-微球蛋白(β2-MG)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些肾功能指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、HOMA-IR水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 黄芪注射液联合螺内酯片治疗糖尿病肾病具有较好的临床疗效,可改善肾功能,调节炎性因子,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the efficacy of Huangqi Injection combined with Spironolactone Tablets in treatment of diabetic nephropathy. Methods Patients (96 cases) with diabetic nephropathy in Jianghan Oil Field General Hospital from September 2015 to August 2017 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Spironolactone Tablets, 20 mg/time, twice daily. Patients in the treatment group were iv administered with Huangqi Injection on the basis of the control group, 40 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and kidney function indexes, inflammatory factors, and HOMA-IR in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.8% and 91.7%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of 24 h mALB, BUN, Scr, UAER, and β2-MG in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the kidney function indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of CRP, TNF-α, IL-6, and HOMA-IR in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the inflammatory factors and HOMA-IR in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Huangqi Injection combined with Spironolactone Tablets has clinical curative effect in treatment of diabetic nephropathy, can improve kidney function, and regulate inflammatory factors, which has a certain clinical application value.
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