目的 探究甲亢灵胶囊联合丙硫氧嘧啶片治疗Graves病的临床疗效。方法 选取2015年2月-2017年1月于西电集团医院收治的Graves病患者134例为研究对象，所有患者按随机数字表法分为对照组和治疗组，每组各67例。对照组口服丙硫氧嘧啶片，起始剂量100 mg/次，3次/d，至临床症状、甲状腺功能改善后逐渐减量至50~100 mg/d。治疗组在对照组治疗基础上口服甲亢灵胶囊，4粒/次，3次/d。两组均连续治疗6个月。观察两组的临床疗效，比较两组的甲状腺功能和甲状腺体积。结果 治疗后，对照组和治疗组的总有效率分别为80.60%、94.03%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清游离三碘甲状腺原氨酸（FT3）、游离四碘甲状腺原氨酸（FT4）、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）水平均明显下降，血清促甲状腺激素（TSH）水平明显上升，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些甲状腺功能指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组甲状腺体积均明显减小，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组甲状腺体积明显小于对照组，两组比较差异具有统计学意义（P<0.05）。结论 甲亢灵胶囊联合丙硫氧嘧啶片治疗Graves病具有较好的临床疗效，能明显改善患者甲状腺功能，减小甲状腺体积，安全性较好，具有一定临床推广应用价值。

Objective To investigate the clinical effect of Jiakangling Capsules combined with Propylthiouracil Tablets in treatment of Graves disease. Methods Patients (134 cases) with Graves disease in Xi'an XD Group Hospital from February 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Propylthiouracil Tablets, starting dosage 100 mg/time, three times daily, after the improvement of clinical symptoms and thyroid function, the dosage gradually reduced to 50-100 mg/d. Patients in the treatment group were po administered with Jiakangling Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and thyroid function and thyroid volume in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.60% and 94.03%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of FT3, FT4, TPOAb, and TGAb in two groups were significantly decreased, but the levels of TSH in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the thyroid function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the thyroid volumes in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the thyroid volumes in the treatment group were significantly smaller than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jiakangling Capsules combined with Propylthiouracil Tablets has clinical curative effect in treatment of Graves disease, can significantly improve thyroid function, reduce thyroid volume, with good safety, which has a certain clinical application value.