目的 探讨养胃颗粒联合铝碳酸镁治疗慢性萎缩性胃炎的临床效果。方法 选取2016年1月-2017年12月广元市第三人民医院收治的慢性萎缩性胃炎患者106例，随机分成对照组和治疗组，每组各53例。对照组患者口服铝碳酸镁片，1.0 g/次，3次/d。治疗组在对照组治疗基础上口服养胃颗粒，1袋/次，3次/d。两组均连续治疗4周。观察两组的临床疗效，比较两组患者治疗前后临床症状积分、胃肠激素、胃蛋白酶原（PG）、白细胞介素-1β（IL-1β）、IL-12、人表皮生长因子（hEGF）、氧化氢酶（CAT）活性、降钙素基因相关肽（CGRP）、内皮素（ET）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为81.13%、94.34%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组胃痛积分、胃中嘈杂积分、胃脘胀满积分、嗳气反酸积分、乏力积分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组治疗后，这些症状积分均显著低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清胃动素（MTL）、PGⅡ、IL-1β、hEGF、ET较治疗前均显著降低，但胃泌素（GAS）、PGⅠ、PGⅠ/PGⅡ、IL-12、CAT、CGRP均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组MLT、PGⅡ、IL-1β、hEGF、ET低于对照组，GAS、PGⅠ、PGⅠ/PGⅡ、IL-12、CAT、CGRP高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 养胃颗粒联合铝碳酸镁治疗慢性萎缩性胃炎具有较好的临床疗效，可明显改善患者症状，调节胃肠激素分泌与氧化应激状态，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Yangwei Granules combined with hydrotalcite in treatment of chronic atrophic gastritis. Methods Patients (106 cases) with chronic atrophic gastritis in the Third People's Hospital of Guangyuan from January 2016 to December 2017 were randomly divided into control (53 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Hydrotalcite Tablets, 1.0 g/time, three times daily. Patients in the treatment group were po administered with Yangwei Granules, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of clinical symptoms integral, gastrointestinal hormone, PG, IL-1β, IL-12, hEGF, CAT, CGRP, and ET in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.13% and 94.34%, respectively, and there was difference between two groups (P < 0.05). After treatment, stomachache integral, noise in the stomach integral, diagnosis swelling integral, belching anti acid integral, lacking in strength integral significantly reduced, and the difference was statistically significant in the same group (P < 0.05). After treatment, these symptoms integrals were significantly lower than those in the control group, and there was difference between two groups (P < 0.05). After treatment, MLT, PGⅡ, IL-1β, hEGF, and ET in two groups significantly reduced, but GAS, PGⅠ, PGⅠ/PGⅡ, IL-12, CAT, and CGRP significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, MLT, PGⅡ, IL-1β, hEGF, and ET in the treatment group were lower than those in the treatment group, but GAS, PGⅠ, PGⅠ/PGⅡ, IL-12, CAT, and CGRP were higher, and there was difference between two groups (P < 0.05). Conclusion Yangwei Granules combined with hydrotalcite has remarkable clinical effect in treatment of chronic atrophic gastritis, and can obviously improve the symptoms, and can regulate the secretion and oxidative stress state of gastrointestinal hormones, which has a certain clinical application value.