目的 探讨喜炎平注射液联合注射用低分子量肝素钙治疗小儿重症肺炎的临床疗效。方法 选取2016年6月-2017年9月荆门市第二人民医院收治的重症肺炎患儿92例为研究对象，根据随机数字表法将所有患儿分为对照组和治疗组，每组各46例。对照组雾化吸入注射用低分子量肝素钙，30 U/kg加入到0.9%氯化钠注射液中30 mL，10~15 min/次，1次/d。治疗组在对照组基础上静脉滴注喜炎平注射液，10 mg/kg加入到5%葡萄糖注射液（或0.9%氯化钠注射液）250 mL中，1次/d。两组患儿在治疗7 d后进行疗效评价。观察两组的临床疗效，比较两组的动脉血气指标、临床症状改善时间、急性生理与慢性健康评分系统（APACHEⅡ）评分、炎性因子。结果 治疗后，对照组和治疗组的总有效率分别为87.0%、97.8%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组pH值和pO₂均有显著升高，pCO₂显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些动脉血气指标改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组憋喘缓解时间、发热缓解时间、咳嗽消失时间、肺部啰音消失时间、住ICU时间、呼吸机支持时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组APACHEⅡ评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组APACHEⅡ评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组肿瘤坏死因子（TNF-α）、超敏C反应蛋白（hs-CRP）水平均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些炎性因子指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 喜炎平注射液联合注射用低分子量肝素钙治疗小儿重症肺炎具有较好的临床疗效，可显著改善临床症状和动脉血气指标，降低炎性因子水平，促进患儿的恢复，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Xiyanping Injection combined with Low Molecular Weight Heparin Calcium for injection in treatment of severe pneumonia in children. Methods Children (92 cases) with severe pneumonia in Jingmen No. 2 People's Hospital from June 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were atomization inhalation administered with Low Molecular Weight Heparin Calcium for injection, 30 U/kg added into normal saline 30 mL, 10-15 min/time, once daily. Patients in the treatment group were in administered with Xiyanping Injection on the basis of the control group, 10 mg/kg added into 5% glucose solution or normal saline 250 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and arterial blood gas indexes, clinical symptom improvement time, APACHEⅡscores, and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.0% and 97.8%, respectively, and there was difference between two groups (P < 0.05). After treatment, pH and pO₂ in two groups were significantly increased, but the pCO₂ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the arterial blood gas indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, dyspnea remission time, fever relieving time, coughing disappearance time, lung rale disappearance time, ICU time, and ventilator support time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the APACHEⅡscores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the APACHEⅡscore in the treatment group were significantly lower than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiyanping Injection combined with Low Molecular Weight Heparin Calcium for injection has clinical curative effect in treatment of severe pneumonia in children, can significantly improve the clinical symptoms and arterial blood gas indexes, reduce the level of inflammatory factors, and promote the recovery of children, which has a certain clinical application value.