目的 探讨槐杞黄颗粒联合布地奈德气雾剂治疗儿童咳嗽变异性哮喘的临床疗效。方法 选取2016年1月-2017年1月吉林大学第一医院儿科收治的咳嗽变异性哮喘患儿106例进行回顾性分析，根据治疗方法的不同将患儿分为对照组和治疗组，每组各53例。对照组吸入布地奈德气雾剂，<2岁：100 μg/次，≥ 2岁：200 μg/次，2次/d。治疗组在对照组基础上口服槐杞黄颗粒，2~3岁：5 g/次，3~12岁：10 g/次，2次/d。两组患儿均连续治疗3个月。观察两组的临床疗效，比较两组的肺功能指标、免疫功能指标、血清免疫球蛋白E（IgE）和细胞因子水平。结果 治疗后，对照组和治疗组的总有效率分别为83.0%、90.6%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组肺活量（FVC）、第一秒呼出气体容积（FEV1）、FEV1/FVC均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些肺功能指标明显高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组CD⁴⁺、CD⁴⁺/CD⁸⁺水平均显著下降，CD⁸⁺水平显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组γ-干扰素（IFN-γ）水平显著升高，IgE、白细胞介素-4（IL-4）水平均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 槐杞黄颗粒联合布地奈德气雾剂治疗儿童咳嗽变异性哮喘具有较好的临床疗效，可改善患儿肺功能，调节免疫功能，降低复发率，具有一定的临床推广应用价值。

Objective To study the clinical efficacy of Huaiqihuang Granules combined with Budesonide Aerosol in treatment of cough variant asthma in children. Methods Children (106 cases) with cough variant asthma in the First Hospital of Jilin University from January 2016 to January 2017 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 53 cases. Children in the control group were inhalation administered with Budesonide Aerosol, ages < 2 years:100 μg/time, ages ≥ 2 years:200 μg/time, twice daily. Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, 2 years ≤ ages < 3 years:5 g/time, 3 years ≤ ages < 12 years:10 g/time, twice daily. Children in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and pulmonary function indexes, immune function indexes, serum IgE, and cytokine levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.0% and 90.6%, respectively, and there was difference between two groups (P < 0.05). After treatment, FVC, FEV1, and FEV1/FVC in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the pulmonary function indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of CD⁴⁺ and CD⁴⁺/CD⁸⁺ in two groups were significantly decreased, but the levels of CD⁸⁺ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the immune function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IFN-γ in two groups were significantly increased, but the levels of IgE and IL-4 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Huaiqihuang Granules combined with Budesonide Aerosol has clinical curative effect in treatment of cough variant asthma in children, can improve pulmonary function, regulate immune function, and decrease recurrence rate, which has a certain clinical application value.