目的 探讨肺力咳合剂联合复方异丙托溴铵治疗婴幼儿急性支气管炎肺炎的临床疗效和安全性。方法 选取2016年3月-2017年3月在郑州儿童医院治疗的急性支气管炎肺炎患儿115例，根据用药的差别分成对照组（57例）和治疗组（58例）。对照组患儿雾化吸入吸入用复方异丙托溴铵溶液，3~4次/d，2.5 mL/d；治疗组患儿在对照组基础上口服肺力咳合剂，10 mL/次，3次/d。两组患儿均经过7 d治疗。观察两组患儿临床疗效，比较治疗前后两组患儿临床症状缓解情况、肌钙蛋白I（cTnI）、降钙素（PCT）和超敏C-反应蛋白（hs-CRP）水平以及血气指标和不良反应情况。结果 治疗后，对照组和治疗组临床总有效率分别为82.46%和96.55%。两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患儿临床症状缓解时间和住院时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患儿cTnI、PCT和hs-CRP血清水平均显著降低（P<0.05）；且治疗组上述指标水平比对照组更低（P<0.05）。治疗后，两组患儿SaO₂和pO₂显著升高，pCO₂显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组血气指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，治疗组患儿不良反应发生率显著低于对照组患儿，两组比较差异具有统计学意义（P<0.05）。结论 肺力咳合剂联合复方异丙托溴铵治疗急性支气管炎肺炎临床疗效好，不良反应少，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Feilike Mistura combined with compound ipratropium bromide in treatment of infantile with acute bronchopneumonia. Methods Infantile (115 cases) with acute bronchopneumonia in Zhengzhou Children's Hospital from March 2016 to March 2017 were randomly divided into control (57 cases) and treatment (58 cases) groups according to different treatment. Infantile in the control group were atomization inhalation administered with Compound Ipratropium Bromide Solution for inhalation, 3-4 times/d, 2.5 mL/d. Infantile in the treatment group were po administered with Feilike Mistura on the basis of the control group, 10 mL/time, three times daily. Infantile in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the alleviative time of clinical symptoms, cTnI, PCT and hs-CRP levels, blood gas indexes and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.46% and 96.55%, respectively, and there were differences between two groups (P < 0.05). After treatment, the alleviative time of clinical symptoms and the hospitalization time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the cTnI, PCT and hs-CRP levels in two groups were significantly decreased (P < 0.05), and these indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the SaO₂ and pO₂ in two groups were significantly increased, but pCO₂was significantly decreased, and there were differences in the same group (P < 0.05). And the blood gas indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). During the treatment, the incidence of adverse reactions in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Feilike Mistura combined with compound ipratropium bromide has good clinical efficacy and less adverse reactions in treatment of infantile with acute bronchopneumonia, which has a certain clinical application value.