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[摘要]
目的 探讨银杏叶胶囊联合单硝酸异山梨酯片治疗冠心病心绞痛的临床疗效。方法 选取2015年2月-2016年12月青海省心脑血管病专科医院收治的冠心病心绞痛患者120例为研究对象,所有患者随机分为对照组和治疗组,每组各60例。对照组口服单硝酸异山梨酯片,10 mg/次,3次/d。治疗组在对照组基础上口服银杏叶胶囊,1粒/次,3次/d。两组患者均连续治疗3个月。观察两组的心绞痛疗效和心电图疗效,比较两组的心绞痛发作和缓解情况、心绞痛积分情况、炎性因子和氧化应激指标。结果 治疗后,对照组和治疗组的心绞痛疗效总有效率分别为80.00%、93.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的心电图疗效总有效率分别为70.00%、86.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组心绞痛发作频率、持续时间、缓解时间和硝酸甘油用量均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组心绞痛积分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些积分明显抵于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、丙二醛(MDA)水平显著降低,超氧化物歧化酶(SOD)水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 银杏叶胶囊联合单硝酸异山梨酯片治疗冠心病心绞痛具有较好的临床疗效,可改善临床症状,降低炎症反应和氧化应激水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To study the effect of Yinxingye Capsules combined with Isosorbide Mononitrate Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (120 cases) with angina pectoris of coronary heart disease in Qinghai Cardio Cerebrovascular Disease Specialist Hospital from February 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Isosorbide Mononitrate Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Yinxingye Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies and electrocardiogram efficacies were evaluated, and the attack and relief of angina pectoris, angina pectoris symptoms, inflammatory factors, and oxidative stress indexes in two groups were compared. Results After treatment, the clinical efficacies of angina pectoris in the control and treatment groups were 80.00% and 93.33%, respectively, and there was difference between two groups (P < 0.05). After treatment, the electrocardiogram efficacies in the control and treatment groups were 70.00% and 86.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, attack frequency, duration, the remission time of angina pectoris and the dosage of nitroglycerin in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, angina pectoris symptoms in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α, IL-6, CRP, and MDA in two groups were significantly decreased, but the levels of SOD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinxingye Capsules combined with Isosorbide Mononitrate Tablets has clinical curative effect in treatment of angina pectoris of coronary heart disease, can improve clinical symptoms, decrease inflammatory response and oxidative stress level, which has a certain clinical application value.
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