目的 探讨灯盏花素注射液联合盐酸替罗非班氯化钠注射液治疗急性心肌梗死的临床疗效。方法 选取2016年9月-2017年9月在滨州医学院烟台附属医院进行治疗的急性心肌梗死患者86例为研究对象，采用计算机将患者随机分为对照组和治疗组，每组各43例。对照组给予盐酸替罗非班氯化钠注射液，初始以10 μg/kg进行静脉推注，3 min内完成，之后以0.15 μg/（kg·min）持续性静脉泵入。治疗组在对照组治疗的基础上静脉滴注灯盏花素注射液，20 mg加入到5%葡萄糖注射液250 mL中，1次/d。两组患者均连续治疗2周。观察两组的临床疗效，比较两组的心功能指标、血清学指标、心绞痛发作次数。结果 治疗后，对照组和治疗组的总有效率分别为79.07%、95.35%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、左心室收缩末期容积（LVESV）均显著下降，左心室射血分数（LVEF）均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些心功能指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清超敏C反应蛋白（hs-CRP）、N末端心房利钠肽（NT-proBNP）、生长分化因子-15（GDF-15）水平均显著降低，心肌营养素-1（CT-1）、白细胞介素-10（IL-10）水平均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组这些血清学指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组心绞痛发作次数显著减少，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组心绞痛发作次数明显优少于对照组，两组比较差异具有统计学意义（P<0.05）。结论 灯盏花素注射液联合盐酸替罗非班氯化钠注射液治疗急性心肌梗死具有较好的临床疗效，可改善临床症状和心功能，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Breviscapine Injection combined with Tirofiban Hydrochloride Sodium Chloride Injection in treatment of acute myocardial infarction. Methods Patients (86 cases) with acute myocardial infarction in Yantai Affiliated Hospital of Binzhou Medical University from September 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were given Tirofiban Hydrochloride Sodium Chloride Injection, initial intravenous injection with 10 μg/kg, and completed within 3 min, then continuous venous pumped with 0.15 μg/(kg·min). Patients in the treatment group were iv administered with Breviscapine Injection on the basis of the control group, 20 mg added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and cardiac function indexes, serological indexes, and the frequency of angina pectoris in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.07% and 95.35%, respectively, and there was difference between two groups (P < 0.05). After treatment, LVEDD, LVESD, and LVESV in two groups were significantly decreased, but the LVEF in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the cardiac function indexes, in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, NT-proBNP, and GDF-15 in two groups were significantly decreased, but the levels of CT-1 and IL-10 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the frequencies of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the frequency of angina pectoris in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Breviscapine Injection combined with Tirofiban Hydrochloride Sodium Chloride Injection has clinical curative effect in treatment of acute myocardial infarction, can improve clinical symptoms and cardiac function, decrease the inflammatory response, which has a certain clinical application value.