目的 探讨丹参多酚酸盐联合尼可地尔治疗冠心病心绞痛的临床效果。方法 选取2016年1月-2017年12月北京市和平里医院收治的146例冠心病心绞痛患者，随机分为对照组和治疗组，每组各73例。对照组口服尼可地尔片，5 mg/次，3次/d。治疗组在对照组基础上静脉滴注注射用丹参多酚酸盐，200 mg加入生理盐水250 mL中充分稀释后给药，1次/d。两组均连续治疗2周。观察两组的临床疗效，比较两组治疗前后硝酸甘油用量、心绞痛发作次数、每次持续时间。比较两组治疗前后低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、红细胞比容（HCT）、红细胞聚集指数（EAI）、肌钙蛋白T（cTnT）、白细胞介素（IL）1β、IL-18、一氧化氮（NO）、超氧化物歧化酶（SOD）、西雅图心绞痛量表（SAQ）各项评分的变化情况。结果 治疗后，对照组和治疗组患者的总有效率分别为82.19%、93.15%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者硝酸甘油用量较治疗前明显减少，心绞痛发作次数、每次持续时间均明显减少，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组硝酸甘油用量、心绞痛发作次数、每次持续时间均明显少于对照组，两组比较差异有统计学意义（P<0.05）。两组治疗后LDL-C、HCT、EAI、cTnT、IL-1β、IL-18水平较治疗前均显著降低，但HDL-C、NO、SOD、SAQ评分升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组LDL-C、HCT、EAI、cTnT、IL-1β、IL-18水平显著低于对照组，HDL-C、NO、SOD、SAQ评分高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 丹参多酚酸盐联合尼可地尔治疗冠心病心绞痛具有较好的临床疗效，可明显改善患者胸闷、胸部绞痛、心电图等症状体征，调节血脂代谢和血液流变学状态，抑制炎症反应，调控氧化应激，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of salvianolate combined with nicorandil in treatment of coronary heart disease with angina pectoris. Methods Patients (146 cases) with coronary heart disease with angina pectoris in Beijing Hepingli Hospital from January 2016 to December 2017 were randomly divided into control (73 cases) and treatment (73 cases) groups. Patients in the control group were po administered with Nicorandil Tablets, 5 mg/time, three times daily. Patients in the treatment group were iv administered with Salvianolate for injection on the basis of the control group, 200 mg added to normal saline 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of nitroglycerin amount, angina attacks frequency and duration in two groups before and after treatment were compared. The changes of LDL-C, HDL-C, HCT, EAI, cTnT, IL-1β, IL-18, NO, SOD, SAQ score in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.19% and 93.15%, respectively, and there was difference between two groups (P < 0.05). After treatment, the nitroglycerin amount, angina attacks frequency and duration in the two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). After treatment, the nitroglycerin amount, angina attacks frequency and duration in the treatment group were lower than those in the treatment group, and there was difference between two groups (P < 0.05). After treatment, LDL-C, HCT, EAI, cTnT, IL-1β, and IL-18 in two groups significantly reduced, but HDL-C, NO, SOD, and SAQ scores significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, LDL-C, HCT, EAI, cTnT, IL-1β, and IL-18 in the treatment group were higher than those in the control group, but HDL-C, NO, SOD, and SAQ scores were lower than those in the control group, and there was difference between two groups (P < 0.05). Conclusions Salvianolate combined with nicorandil has remarkable clinical effect in treatment of coronary heart disease with angina pectoris, and can obviously improve the symptoms such as chest tightness, chest colic and electrocardiogram, and regulate blood lipid metabolism and hemorheology, also can inhibit inflammatory response and regulate oxidative stress, which has a certain clinical application value.