目的 分析2014—2016年解放军总医院海南分院口服抗高血压药使用情况及变化趋势，为临床合理用药和管理提供参考依据。方法 通过医院信息系统（HIS）提取2014—2016年解放军总医院海南分院口服抗高血压药使用相关数据，对各类药品的用药金额和用药频度（DDDs）进行统计分析。结果 2014—2016年，口服抗高血压药的用药总金额不断上升，其中钙通道阻滞剂（CCB）、血管紧张素Ⅱ受体拮抗剂（ARB）、复方制剂、β受体阻断剂、血管紧张素转化酶抑制剂（ACEI）用药金额构成比分列前5位。苯磺酸氨氯地平片的用药金额始终处于首位，并呈逐年上升趋势；富马酸比索洛尔片的DDDs一直处于前两位，且逐年上升趋势；坎地沙坦酯片的用药金额构成比及DDDs均呈较为明显的上升趋势；缬沙坦胶囊的用药金额构成比及DDDs逐年下降。结论 解放军总医院海南分院口服抗高血压药的使用情况基本符合当前指南推荐的用药原则，但个别品种用量呈持续增长势态，需密切关注、加强监管，确保临床用药更为规范、合理。

Objective To analyze the use condition and trend of oral antihypertensive drugs in Hainan Branch of PLA General Hospital from 2014 to 2016, and in order to provide reference and management for clinical rational use of drugs. Methods The relevant data of utilization of oral antihypertensive drugs in Hainan Branch of PLA General Hospital from 2014 to 2016 was selected from hospital information systems (HIS), and consumption sum and defined daily doses (DDDs) of all kinds of oral antihypertensive drugs were analyzed. Results From 2014 to 2016, the total amounts of oral antihypertensive drugs continuously rose for three years. The composing ratio of consumption sum of Calcium channel blockers (CCB), angiotensin Ⅱ receptor antagonist (ARB), compound preparation, β-receptor blocker, and angiotensin converting enzyme inhibitor (ACEI) ranked the top five. Consumption sum of Amlodipine Besylate Tablets were always in the first place with an increasing trend year by year. DDDs of Bisoprolol Fumarate Tablets remained the second place with an increasing trend year by year. The composing ratio of consumption sum and DDDs had shown an obvious increase for Candesartan Ester Tablets, while valsartan capsule came down year by year. Conclusion The use of oral antihypertensive drugs in Hainan Branch of PLA General Hospital ultimately complys with medication principles of context guidelines recommend. But the consumption of some varieties presents an increasing tendency continuously. For these varieties, more attention should be given, and supervision should be strengthened to insure the standard and rational drug use in clinic.