目的 探讨瘀血痹片联合玻璃酸钠注射液治疗膝关节骨性关节炎的临床疗效。方法 选取2015年2月—2016年7月在汉川市人民医院骨科进行治疗的膝关节骨性关节炎患者86例为研究对象，采用双盲法将所有患者分为对照组和治疗组，每组各43例。对照组关节腔内注射玻璃酸钠注射液，2.5 mL/次，1次/周。治疗组在对照组基础上口服瘀血痹片，5片/次，3次/d。两组患者均持续治疗5周。观察两组的临床疗效，比较两组的Lysholm、VAS和ADL评分以及血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为81.40%、93.02%，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组Lysholm和ADL评分显著升高，VAS评分显著下降，同组治疗前后比较差异具有统计学意义（P < 0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异有统计学意义（P < 0.05）。治疗后，两组血清C反应蛋白（CRP）、白细胞介素-8（IL-8）和肿瘤坏死因子（TNF-α）水平显著降低，同组治疗前后比较差异具有统计学意义（P < 0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P < 0.05）。结论 瘀血痹片联合玻璃酸钠注射液治疗膝关节骨性关节炎具有较好的临床疗效，可减轻患者疼痛，提升生活质量，改善关节炎症，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Yuxuebi Tablets combined with Sodium Hyaluronate Injection in treatment of knee osteoarthritis. Methods Patients (86 cases) with knee osteoarthritis in Department of Orthopaedics of Hanchuan People's Hospital from February 2015 to July 2016 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were intra articular injection administered with Sodium Hyaluronate Injection, 2.5 mL/time, once weekly. Patients in the treatment group were po administered with Yuxuebi Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacies were evaluated, and Lysholm scores, VAS scores, ADL scores, and serological indexes were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 93.02%, respectively, and there was difference between two groups (P < 0.05). After treatment, Lysholm scores and VAS scores in two groups were significantly increased, but ADL scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of CRP, IL-8, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yuxuebi Tablets combined with Sodium Hyaluronate Injection has clinical curative effect in treatment of knee osteoarthritis, can relieve the pain of the patients, enhance the quality of life, improve inflammation of the joints, which has a certain clinical application value.