目的 探讨玉蓝降糖联合二甲双胍治疗2型糖尿病患者的有效性和安全性。方法 选取河北省第七人民医院2015年12月—2016年12月收治的2型糖尿病患者125例，随机分成对照组（62例）和治疗组（63例）。对照组患者口服盐酸二甲双胍片，2片/次，2次/d，根据病情适当调整剂量。治疗组在对照组基础上口服玉蓝降糖胶囊，4粒/次，3次/d。所有患者均治疗3个月。观察两组患者临床疗效，比较治疗前后两组患者空腹血糖（FPG）、餐后2 h血糖（2 h PG）和糖化血红蛋白（HbA1c）以及临床指标水平和不良反应情况。结果 治疗后，对照组临床总有效率为82.26%，显著低于治疗组的96.83%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清FPG、2 h PG和HbA1c水平显著降低（P<0.05）；且治疗组患者FPG、2 h PG和HbA1c水平明显低于对照组（P<0.05）。治疗后，两组患者BMI指数、收缩压（SBP）、尿酸（UA）和三酰甘油（TG）水平均显著降低（P<0.05）；且治疗组患者各指标改善情况均要明显低于对照组（P<0.05）。治疗期间，对照组不良反应发生率为19.35%，明显高于治疗组的4.76%，两组比较差异具有统计学意义（P<0.05）。结论 玉蓝降糖联合二甲双胍治疗2型糖尿病疗效好，安全性高，具有一定的临床推广应用价值。

objective To explore the clinical efficacy and safety of Yulan Jiangtang Capsules combined with metformin in treatment of type 2 diabetes. Methods Patients (125 cases) with type 2 diabetes in the Seventh People's Hospital of Hebei Province from December 2015 to December 2016 were randomly divided into control (62 cases) and treatment (63 cases) groups. Patients in the control group were po administered with Metformin Hydrochloride Tablets, 2 tablets/time, twice daily, and adjust the dose according to the disease. Patients in the treatment group were po administered with Yulan Jiangtang Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and FPG, 2 h PG, HbA1c, the clinical indexes levels and adverse events in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 82.26%, which was significantly lower than 96.83% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FPG, 2 h PG, and HbA1c levels in two groups were significantly decreased (P < 0.05). And the FPG, 2 h PG, and HbA1c levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the BMI index, SBP, UA and TG levels in two groups were significantly decreased (P < 0.05). And these indicators in the treatment group were significantly lower than those in the control group (P < 0.05). During the treatment, the incidence of adverse reactions in the control group was 19.35%, which was significantly higher than 4.76% in the treatment group, with significant difference between two groups (P < 0.05). Conclusion Yulan Jiangtang Capsules combined with metformin has good clinical efficacy in treatment of type 2 diabetes with high safety, which has a certain clinical application value.

保定市科学技术研究与发展指导计划项目（14ZF080）