目的 分析2014—2016年成都地区25家医院质子泵抑制剂（PPIs）的使用情况，为临床合理用药提供参考。方法 抽取成都地区25家医院2014—2016年PPIs的使用数据，对销售金额、用药频度（DDDs）、日均费用（DDC）和排序比（B/A）等进行回顾性分析。结果 2014—2016年成都地区25家医院PPIs的销售金额连续3年呈递减趋势，同时总DDDs先增加后减少，2016年呈现最低值。口服类PPIs以雷贝拉唑钠位居DDDs排名的第1位，注射类PPIs中以注射用泮托拉唑钠连续3年均稳居销售金额和DDDs排名的第1位。口服类PPIs中艾普拉唑的DDC最大，且同步性较好。注射类PPIs以艾司奥美拉唑的DDC最大，在同步性方面，泮托拉唑同步性最好。结论 通过加强合理用药监控手段，成都地区25家医院PPIs的使用量得到有效控制，使用日趋合理化。

Objective To investigate the utilization of proton pump inhibitors (PPIs) in 25 hospitals in Chengdu area from 2014 to 2016, and to provide reference for clinical rational drug use. Methods Data of PPIs in 25 hospitals in Chengdu area from 2014 to 2016 were selected, and consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and sequence ratio (B/A) of PPIs were retrospectively analyzed. Results Consumption sum of PPIs in 25 hospitals in Chengdu area from 2014 to 2016 showed a decreasing trend for three consecutive years. Total DDDs was increased firstly and then decreased, and showed a minimum in 2016. DDDs of rabeprazole sodium in oral preparation ranked the first. Consumption sum and DDDs of Pantoprazole Sodium for injection in PPIs for injection ranked the first for three consecutive years. DDC of ilaprazole in oral preparation was the biggest with better synchronism. DDC of esomeprazole in PPIs for injection was the biggest, while the synchronism of pantoprazole was best. Conclusion By strengthening the monitoring methods of rational drug use, the use of PPIs in 25 hospitals in Chengdu area has been effectively controlled, and has become more and more rationalized.

四川省教育厅科研项目（16ZA0290）